{"id":"W4295779887","doi":"10.1101/2022.09.11.507480","title":"Hydrogen Peroxide Production by Epidermal Dual Oxidase 1 Regulates Nociceptive Sensory Signals","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development","funders":"Nemzeti Kutatási, Fejlesztési és Innovaciós Alap; Magyar Tudományos Akadémia; National Research, Development and Innovation Office; Innovációs és Technológiai Minisztérium; Hungarian Scientific Research Fund","keywords":"NADPH oxidase; Cell biology; Nociceptor; Sensory system; Sensory neuron; Chemistry; Dorsal root ganglion; Nociception; Neuroscience; Biology; Biochemistry; Reactive oxygen species; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009583336,0.0002076662,0.0001540719,0.0001722089,0.0001186509,0.0002741061,0.00009961236,0.0001931739,0.0009084551],"category_scores_gemma":[0.00007854246,0.00008363948,0.000131451,0.00008685357,0.0001463905,0.0001885321,0.0001764897,0.0002602055,0.0002085772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280405,"about_ca_system_score_gemma":0.00007675126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002384282,"about_ca_topic_score_gemma":0.0002660433,"domain_scores_codex":[0.9999516,0.00000600844,0.000002514043,0.00001399052,0.00001181917,0.00001411521],"domain_scores_gemma":[0.9999499,0.000005548099,0.00001626899,0.000004165936,0.000008533903,0.00001555831],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008156369,0.00001061749,0.0004505915,0.00002298622,0.000002580452,0.00005652484,0.00000911981,0.00002839018,0.9982249,0.000132435,0.000044101,0.0009361201],"study_design_scores_gemma":[0.0000230758,0.0001247786,0.02663265,0.000007141115,0.00001109705,0.0002754566,0.00005068324,0.001612094,0.9688288,0.0003651035,0.002063158,0.00000594706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918025,0.002835922,0.003660511,0.0001370538,0.00005537801,0.00001229186,0.0001971485,0.00006727729,0.001231962],"genre_scores_gemma":[0.9960856,0.0005630046,0.0009640282,0.0000204907,0.00001345137,0.000006552825,0.0001301383,0.00001202183,0.002204709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009084551,"threshold_uncertainty_score":0.003039122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02241811238221327,"score_gpt":0.2329113220150133,"score_spread":0.2104932096328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}