{"id":"W4295793359","doi":"10.1620/tjem.2022.j078","title":"A Pilot Study of Whole-Brain Low-Intensity Pulsed Ultrasound Therapy for Early Stage of Alzheimer’s Disease (LIPUS-AD): A Randomized, Double-Blind, Placebo-Controlled Trial","year":2022,"lang":"en","type":"article","venue":"The Tohoku Journal of Experimental Medicine","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Agency for Medical Research and Development","keywords":"Medicine; Randomized controlled trial; Placebo; Adverse effect; Clinical endpoint; Dementia; Clinical trial; Internal medicine; Extracorporeal shockwave therapy; Surgery; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002003935,0.000277873,0.001453224,0.0002002147,0.0002014251,0.00001535801,0.0004767835,0.00002178853,0.0003799364],"category_scores_gemma":[0.000157861,0.000171113,0.0003538133,0.0002193387,0.0002576002,0.00009889247,0.00003728662,0.0003358722,8.227474e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006983046,"about_ca_system_score_gemma":0.00007698734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001263762,"about_ca_topic_score_gemma":0.000005773251,"domain_scores_codex":[0.9972933,0.0002949015,0.00131075,0.0001668954,0.0006947091,0.0002394558],"domain_scores_gemma":[0.9971225,0.001494136,0.0006693142,0.0003787185,0.0001653587,0.0001699891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7737378,0.002189368,0.00001265849,0.00001001581,0.001274512,0.000004286892,0.005757141,0.00135846,0.2151895,0.00004363944,0.0003714034,0.00005124509],"study_design_scores_gemma":[0.9654516,0.01051652,0.00003713057,0.00004138245,0.0005895364,0.00001977207,0.009226449,0.0003959552,0.01326854,0.00008256906,0.0002121539,0.0001584169],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840608,0.00623339,0.0002896917,0.0006659094,0.0006573412,0.007924751,0.00003908571,0.00002624385,0.0001028426],"genre_scores_gemma":[0.9978814,0.00005897411,0.00003736015,0.0001155162,0.0003280641,0.001335677,0.0000105763,0.00005053405,0.0001819031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2019209,"threshold_uncertainty_score":0.6977785,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04782935388742306,"score_gpt":0.3098401325530789,"score_spread":0.2620107786656558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}