{"id":"W4295793359","doi":"10.1620/tjem.2022.j078","title":"A Pilot Study of Whole-Brain Low-Intensity Pulsed Ultrasound Therapy for Early Stage of Alzheimer’s Disease (LIPUS-AD): A Randomized, Double-Blind, Placebo-Controlled Trial","year":2022,"lang":"en","type":"article","venue":"The Tohoku Journal of Experimental Medicine","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Agency for Medical Research and Development","keywords":"Medicine; Randomized controlled trial; Placebo; Adverse effect; Clinical endpoint; Dementia; Clinical trial; Internal medicine; Extracorporeal shockwave therapy; Surgery; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003913234,0.002104231,0.004380883,0.0006279438,0.0008220961,0.001176867,0.0009937803,0.003195486,0.009639769],"category_scores_gemma":[0.002887234,0.0007271771,0.002170528,0.0005011566,0.001523408,0.00147947,0.0005968471,0.003176485,0.001594998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004733717,"about_ca_system_score_gemma":0.001590947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005176167,"about_ca_topic_score_gemma":0.0008797315,"domain_scores_codex":[0.9986896,0.0006614132,0.000113925,0.0002417106,0.000106036,0.0001872955],"domain_scores_gemma":[0.9983165,0.0005352824,0.0002683745,0.0001684798,0.0002087961,0.0005025751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.965417,0.01781309,0.0002331531,0.001203461,0.0006300632,0.00006313216,0.00007006477,0.0001049618,0.003479173,0.0001270752,0.0006714704,0.01018733],"study_design_scores_gemma":[0.9199057,0.07853679,0.0005008437,0.00003014656,0.0001733041,0.000015978,0.00001433769,0.00009361812,0.0001531189,0.00006934195,0.0004992507,0.000007646549],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9280815,0.01229228,0.002701174,0.002046539,0.002481336,0.04562129,0.002260218,0.000433696,0.004082046],"genre_scores_gemma":[0.8947479,0.006292234,0.007543353,0.003681224,0.001766684,0.07693729,0.001905223,0.00005261154,0.00707351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009639769,"threshold_uncertainty_score":0.03224826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04782935388742306,"score_gpt":0.3098401325530789,"score_spread":0.2620107786656558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}