{"id":"W4295817391","doi":"10.1016/j.annonc.2022.07.782","title":"658MO Pembrolizumab (pembro) vs standard-of-care (SOC) in previously treated recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): 6-year follow-up of KEYNOTE-040","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Merck Sharp and Dohme; Merck","keywords":"Medicine; Docetaxel; Cetuximab; Pembrolizumab; Head and neck squamous-cell carcinoma; Internal medicine; Oncology; Head and neck cancer; Radiation therapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008759483,0.0003322937,0.001020802,0.0002626534,0.0002817414,0.0006645651,0.0003924915,0.0006868538,0.002435119],"category_scores_gemma":[0.0007650054,0.0001811909,0.001232067,0.0003289077,0.000277396,0.0008234634,0.0002775032,0.001219649,0.0004439946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007726243,"about_ca_system_score_gemma":0.0005790524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002541555,"about_ca_topic_score_gemma":0.004735362,"domain_scores_codex":[0.9996628,0.00008014953,0.00002045813,0.0000781027,0.00003755283,0.0001209716],"domain_scores_gemma":[0.9996077,0.00008327521,0.00008259548,0.00003591644,0.00002586589,0.0001646141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7735005,0.01574884,0.07001587,0.0004988003,0.003589503,0.0002664308,0.0002189859,0.001461342,0.008282038,0.0001749498,0.00311306,0.1231297],"study_design_scores_gemma":[0.07685778,0.3942811,0.5104603,0.0001829905,0.005455657,0.0004803626,0.0004503878,0.002766326,0.003549653,0.0004348393,0.005009786,0.000070892],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970564,0.001603513,0.00002930169,0.00008818707,0.00007769155,0.00004368925,0.0004225098,0.000008403139,0.0006703497],"genre_scores_gemma":[0.9972005,0.0007668796,0.00006487706,0.0001854125,0.00006828299,0.00004378508,0.0007368263,0.000003432948,0.0009300341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002541555,"threshold_uncertainty_score":0.008146286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04529320590359399,"score_gpt":0.3422312377587912,"score_spread":0.2969380318551972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}