{"id":"W4295819105","doi":"10.1016/j.annonc.2022.07.589","title":"460MO Preliminary results from a phase I study using the bispecific, human epidermal growth factor 2 (HER2)-targeting antibody-drug conjugate (ADC) zanidatamab zovodotin (ZW49) in solid cancers","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Zymeworks (Canada); Jewish General Hospital","funders":"","keywords":"Medicine; Tolerability; Adverse effect; Internal medicine; Antibody-drug conjugate; Phases of clinical research; Oncology; Gastroenterology; Toxicity; Antibody; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008496666,0.0008901042,0.0009607894,0.0002065138,0.0004090573,0.000751908,0.0004872214,0.0008503076,0.004112676],"category_scores_gemma":[0.000516971,0.0003055918,0.0008582661,0.0002200849,0.0003380721,0.0004377338,0.0002133736,0.002041874,0.001180494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005388516,"about_ca_system_score_gemma":0.0007967011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002305399,"about_ca_topic_score_gemma":0.006096432,"domain_scores_codex":[0.9997519,0.00009211093,0.00001318854,0.00003071444,0.00003671103,0.00007533176],"domain_scores_gemma":[0.9996589,0.00008709139,0.00003320562,0.00003194797,0.00003616945,0.0001525217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1084842,0.04470379,0.0141635,0.001283446,0.001669985,0.00199598,0.0008220968,0.007194214,0.5330153,0.001029309,0.02078569,0.2648525],"study_design_scores_gemma":[0.1112368,0.5684963,0.07125232,0.0001559073,0.001936298,0.005094252,0.0002572663,0.00527009,0.1563471,0.001081547,0.07875657,0.0001155433],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628122,0.01049487,0.003970589,0.002067042,0.0004165208,0.002411999,0.004131662,0.0002922926,0.01340279],"genre_scores_gemma":[0.9571094,0.007955487,0.004306871,0.002183758,0.0002317493,0.001244269,0.01195029,0.0001406369,0.01487755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004112676,"threshold_uncertainty_score":0.0137583,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1567433262462493,"score_gpt":0.4685276178053498,"score_spread":0.3117842915591005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}