{"id":"W4295819112","doi":"10.1016/j.annonc.2022.07.783","title":"659MO Pembrolizumab with or without chemotherapy for first-line treatment of recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): 5-year results from KEYNOTE-048","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Merck Sharp and Dohme; Eisai; Merck KGaA; Sanofi; AstraZeneca; Amgen; Pfizer; Bristol-Myers Squibb","keywords":"Pembrolizumab; Medicine; Internal medicine; Head and neck squamous-cell carcinoma; Oncology; Chemotherapy; Population; Head and neck cancer; Immunotherapy; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001107836,0.0006091572,0.001289487,0.000356291,0.0003534568,0.0007309118,0.000569017,0.0007527278,0.00433159],"category_scores_gemma":[0.0004166795,0.000234894,0.001684359,0.0003324246,0.0003368089,0.0008225008,0.0003699927,0.002007873,0.001001102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008022774,"about_ca_system_score_gemma":0.0008008044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00181705,"about_ca_topic_score_gemma":0.005688911,"domain_scores_codex":[0.9996907,0.00008114801,0.00001765878,0.00006757151,0.00004209462,0.0001010012],"domain_scores_gemma":[0.9997632,0.00004312033,0.00004407606,0.00001975466,0.00001881353,0.0001110661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.4256615,0.0242452,0.01425634,0.002660935,0.004409209,0.0004384666,0.000178844,0.002564096,0.01951726,0.0004506957,0.01730702,0.4883104],"study_design_scores_gemma":[0.3572336,0.4082336,0.1787565,0.0008846335,0.007336898,0.001330435,0.000256411,0.003023178,0.007463096,0.0006315571,0.03475561,0.00009450057],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9505828,0.03109427,0.0005836691,0.001316438,0.0007461738,0.0008782524,0.004529967,0.0001790827,0.01008936],"genre_scores_gemma":[0.9563345,0.02045335,0.001370268,0.002492127,0.0004562977,0.0005971361,0.009394472,0.00005634296,0.008845554],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00433159,"threshold_uncertainty_score":0.0144906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08290346032636627,"score_gpt":0.3642580752485326,"score_spread":0.2813546149221663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}