{"id":"W4295827764","doi":"10.1016/j.annonc.2022.07.1312","title":"1189TiP Phase II study of anti-TIGIT GSK4428859A (GSK’859A)/EOS-448 + anti-CD96 GSK6097608 (GSK’608) + anti-PD-1 dostarlimab in non-small cell lung cancer (NSCLC)","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"William Osler Health System; Brampton Civic Hospital","funders":"","keywords":"TIGIT; Medicine; Lung cancer; non-small cell lung cancer (NSCLC); Cancer research; Atezolizumab; Internal medicine; Oncology; Cancer; Immunotherapy; A549 cell; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00125086,0.001797235,0.002313264,0.0005697042,0.0004386699,0.001279233,0.001321395,0.001541474,0.008713271],"category_scores_gemma":[0.0004239783,0.0008834111,0.00211988,0.0004396847,0.0009767802,0.0009078433,0.0004413324,0.00400856,0.0030834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001098021,"about_ca_system_score_gemma":0.001952055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002101921,"about_ca_topic_score_gemma":0.004830393,"domain_scores_codex":[0.9995791,0.0001368872,0.00002322822,0.00007220704,0.000038025,0.0001505871],"domain_scores_gemma":[0.9996167,0.0000347378,0.00004532837,0.00004852879,0.00002496381,0.0002298323],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7502144,0.07961654,0.002784086,0.0009899481,0.001701821,0.0002381556,0.0001567507,0.002194035,0.05070127,0.00051135,0.008132936,0.1027587],"study_design_scores_gemma":[0.642476,0.3426834,0.004824677,0.00003178576,0.0004777552,0.0001852298,0.00004138672,0.000826332,0.003794224,0.0002039667,0.004430906,0.00002438465],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790899,0.003795013,0.001026004,0.000918049,0.0006196529,0.004265879,0.003668153,0.0002944734,0.006322967],"genre_scores_gemma":[0.9654313,0.003488849,0.002837153,0.001582066,0.0003191864,0.004765413,0.009328571,0.00008921458,0.01215834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008713271,"threshold_uncertainty_score":0.02914882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05462985005233335,"score_gpt":0.3872184693149579,"score_spread":0.3325886192626246,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}