{"id":"W4295837313","doi":"10.1016/j.annonc.2022.07.1825","title":"1747P Impact of prior chemotherapy (Chemo) on pembrolizumab (Pembro) response in urothelial cancer (UC): Exploratory analysis of the phase III KEYNOTE-045 study","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Cancer Institute; Foundation Medicine; Merck Sharp and Dohme; EMD Serono; Genentech; Ipsen; Astellas Pharma; Calithera Biosciences; Sanofi Genzyme; Incyte; Exelixis; Merck KGaA; Merck; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Docetaxel; Cisplatin; Medicine; Exploratory analysis; Urothelial cancer; Pembrolizumab; Oncology; Cancer; Chemotherapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006626175,0.0008371816,0.001314808,0.0002756552,0.0003423816,0.001315008,0.0009819509,0.001256488,0.005319709],"category_scores_gemma":[0.00543748,0.0004227232,0.004879521,0.0006522338,0.0006372678,0.001083698,0.000692163,0.002193271,0.0006014904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006898386,"about_ca_system_score_gemma":0.001050925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044675,"about_ca_topic_score_gemma":0.001978287,"domain_scores_codex":[0.9969403,0.002239631,0.0001061564,0.0002815861,0.0001774367,0.0002550278],"domain_scores_gemma":[0.9954602,0.002606815,0.0009007219,0.0004409879,0.0001485215,0.0004427274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.8389887,0.002736279,0.07851522,0.0009633166,0.02604811,0.0002063486,0.0001057351,0.002953466,0.005686976,0.0003189187,0.003992958,0.03948401],"study_design_scores_gemma":[0.2124891,0.1958845,0.5403771,0.0002746968,0.0341486,0.0004961945,0.0002685862,0.003686945,0.00371248,0.001033086,0.007522406,0.000106463],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886233,0.003383228,0.0004827347,0.000518934,0.00009475235,0.0002617789,0.004609585,0.00003404971,0.001991637],"genre_scores_gemma":[0.9948809,0.0005203544,0.0003465364,0.0003791754,0.0001194148,0.0001664796,0.002401804,0.00002448901,0.001160841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006626175,"threshold_uncertainty_score":0.035043,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08060300676111953,"score_gpt":0.4490655589239205,"score_spread":0.3684625521628009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}