{"id":"W4295837323","doi":"10.1016/j.annonc.2022.07.1827","title":"1749P Association between immune-mediated adverse events (imAEs) and outcomes in metastatic urothelial cancer (mUC) treated with durvalumab (D) alone or in combination with tremelimumab (T) in the DANUBE study","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Bristol-Myers Squibb Canada; Astellas Pharma Canada; Roche; Sanofi; Merck; Janssen Pharmaceuticals; Bayer; AstraZeneca; Pfizer","keywords":"Medicine; Durvalumab; Internal medicine; Hazard ratio; Cancer; Adverse effect; Oncology; Proportional hazards model; Immune system; Immunotherapy; Immunology; Confidence interval; Pembrolizumab","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006626465,0.0002725852,0.0004817083,0.0002545558,0.000226241,0.0006274116,0.0003990187,0.000336349,0.002139006],"category_scores_gemma":[0.001297991,0.0001478946,0.0008152269,0.0005721448,0.0001630559,0.0002921188,0.0003209316,0.0008539041,0.0001700854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003961935,"about_ca_system_score_gemma":0.0003689453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003849283,"about_ca_topic_score_gemma":0.006435193,"domain_scores_codex":[0.9995906,0.0001612718,0.00003799557,0.00008581096,0.00006728362,0.00005705247],"domain_scores_gemma":[0.9992521,0.0001939757,0.0002938399,0.00005878934,0.00005604964,0.0001450872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01689052,0.0001787136,0.959177,0.0002075152,0.003554447,0.0004302698,0.00004815194,0.0004607394,0.002547462,0.0002818134,0.002130558,0.01409286],"study_design_scores_gemma":[0.001077788,0.0008571192,0.992579,0.00003631774,0.001531227,0.0003792147,0.00006223864,0.0005933709,0.0004686697,0.0002126527,0.00218693,0.00001544865],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934694,0.002547312,0.00009105333,0.0003366939,0.00005363173,0.00001385874,0.00198538,0.0000068389,0.001495831],"genre_scores_gemma":[0.99804,0.0004238473,0.00006470728,0.0001062908,0.00004913196,0.00001650593,0.0007697503,0.000003467281,0.0005262637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003849283,"threshold_uncertainty_score":0.007653773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05725195480782379,"score_gpt":0.3696447928145789,"score_spread":0.3123928380067551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}