{"id":"W4295837344","doi":"10.1016/j.annonc.2022.07.1502","title":"1370P Detection of mutations in homologous recombination repair (HRR) genes in tumour tissue (TT) and circulating tumour DNA (ctDNA) from patients (pts) with metastatic castrate-resistant prostate cancer (mCRPC) in the phase III PROpel trial","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Ipsen; Astellas Pharma; Svenska Forskningsrådet Formas; Exelixis; Gilead Sciences; Merck; Genentech; Bristol-Myers Squibb; AstraZeneca; Pfizer; Merck Sharp and Dohme; Ono Pharmaceutical","keywords":"Medicine; Internal medicine; Prostate cancer; Cancer; Gastroenterology; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003771491,0.0002736009,0.0004413577,0.0003904678,0.0001729918,0.0005916114,0.000271036,0.0004370683,0.004110798],"category_scores_gemma":[0.0009115413,0.0001649122,0.0001928495,0.0004234512,0.0002613692,0.0001820235,0.0002214981,0.0004920721,0.0004097789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003518357,"about_ca_system_score_gemma":0.0002767478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008865045,"about_ca_topic_score_gemma":0.0009389696,"domain_scores_codex":[0.9997203,0.00006714941,0.00001600857,0.00007242967,0.00006982433,0.00005427495],"domain_scores_gemma":[0.9996539,0.0001430907,0.00005976935,0.00001752341,0.00003222221,0.00009350467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.05475904,0.0009181811,0.4759255,0.000363196,0.0004304627,0.002103011,0.000423316,0.001758983,0.3563667,0.0007380885,0.004836221,0.1013774],"study_design_scores_gemma":[0.005252773,0.02992378,0.8331054,0.00005820268,0.0006353493,0.008924548,0.0003680228,0.00507217,0.1041907,0.001162851,0.01125442,0.00005167355],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970253,0.0004687447,0.0002189945,0.0001073576,0.00002314869,0.0000179857,0.001103705,0.00002771455,0.001006961],"genre_scores_gemma":[0.9976929,0.0001065221,0.0002144483,0.00006611007,0.00001113628,0.00001605532,0.001185008,0.00001109067,0.0006965612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004110798,"threshold_uncertainty_score":0.01375192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03309000354004846,"score_gpt":0.3274764585694808,"score_spread":0.2943864550294323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}