{"id":"W4295837466","doi":"10.1016/j.annonc.2022.08.072","title":"LBA67 Phase III randomized study comparing perioperative nivolumab (nivo) versus observation in patients (Pts) with renal cell carcinoma (RCC) undergoing nephrectomy (PROSPER, ECOG-ACRIN EA8143), a National Clinical Trials Network trial","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Joseph’s Healthcare Hamilton","funders":"","keywords":"Medicine; Nivolumab; Renal cell carcinoma; Perioperative; Randomized controlled trial; Oncology; Internal medicine; Nephrectomy; Clinical trial; Kidney cancer; Cancer; Surgery; Kidney; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001286751,0.001528975,0.002689902,0.0002743704,0.0004189045,0.001183989,0.000723081,0.001061253,0.006372375],"category_scores_gemma":[0.001492601,0.0006116413,0.002913412,0.0003570828,0.0009234863,0.0007749341,0.0004316722,0.003948635,0.001249669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000967327,"about_ca_system_score_gemma":0.00170817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001991006,"about_ca_topic_score_gemma":0.006374757,"domain_scores_codex":[0.9995715,0.0002245189,0.00002225891,0.00007937678,0.00003005511,0.00007230958],"domain_scores_gemma":[0.9992971,0.0001749075,0.0001726759,0.00006196509,0.00004514109,0.0002481077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9761078,0.003265167,0.0008979988,0.0008614333,0.002006241,0.00002328168,0.0000333239,0.0003573676,0.001541283,0.0001396368,0.001538442,0.01322798],"study_design_scores_gemma":[0.9590654,0.03587351,0.002292018,0.00007203605,0.001156142,0.00002758551,0.00002725802,0.0003098502,0.0001965815,0.0001616412,0.0008032721,0.00001466273],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979553,0.009464645,0.0007498072,0.001153584,0.001170562,0.002302162,0.002188266,0.0001676374,0.003250357],"genre_scores_gemma":[0.9809207,0.004023473,0.001841076,0.00222884,0.0006352065,0.003089818,0.00283039,0.00004742816,0.004383138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006372375,"threshold_uncertainty_score":0.02131766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3014561490735008,"score_gpt":0.4595597350834706,"score_spread":0.1581035860099698,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}