{"id":"W4295858195","doi":"10.2139/ssrn.4211174","title":"Biotransformation of Bisphenol-A Bis(Diphenyl Phosphate): In Vitro, in Silico, and (Non-) Target Analysis for Metabolites in Rat and Bird Liver Microsomal Models","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University","funders":"","keywords":"Biotransformation; Chemistry; Microsome; Bioaccumulation; Triphenyl phosphate; Biochemistry; In silico; Toxicokinetics; Bisphenol A; Glutathione; Metabolite; Metabolism; Environmental chemistry; In vitro; Chromatography; Enzyme; Organic chemistry; Fire retardant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002331314,0.0006156229,0.0002552068,0.000368851,0.000275926,0.0003206698,0.0002383971,0.0004132777,0.001299093],"category_scores_gemma":[0.0002240565,0.000276171,0.0005343133,0.0002469292,0.0001932764,0.0002589014,0.000222123,0.0004150805,0.0006104614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004446747,"about_ca_system_score_gemma":0.0005312549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009121499,"about_ca_topic_score_gemma":0.01042843,"domain_scores_codex":[0.9998277,0.00004534265,0.000008901869,0.00004890088,0.00003780436,0.00003123082],"domain_scores_gemma":[0.9998835,0.00002448054,0.00002152023,0.00001630315,0.00002952804,0.0000245809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006381303,0.00008864616,0.0008799251,0.00007750171,0.00004080553,0.00006226802,0.00003727328,0.001221515,0.9934871,0.00009500481,0.0000568554,0.003314838],"study_design_scores_gemma":[0.000006638455,0.0007002785,0.002617696,0.000002254439,0.00005351583,0.00007699931,0.00002197638,0.001836631,0.9939587,0.00002186659,0.000697269,0.000006208379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888932,0.0007146561,0.007633048,0.00005668957,0.00001792266,0.00005532584,0.001123008,0.00008132504,0.001424862],"genre_scores_gemma":[0.9884089,0.001125504,0.004155657,0.00002596491,0.000004284821,0.00004699234,0.001495912,0.00003209487,0.004704755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009121499,"threshold_uncertainty_score":0.0181368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004816388456644528,"score_gpt":0.251276765633827,"score_spread":0.2464603771771825,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}