{"id":"W4295874966","doi":"10.1101/2022.09.08.507183","title":"Histone deacetylase 3 regulates microglial function through histone deacetylation","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Vancouver Coastal Health","funders":"Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"HDAC3; Microglia; Histone deacetylase; Acetylation; Histone; Cell biology; Biology; Inflammation; Neuroinflammation; Histone H4; Histone deacetylase inhibitor; HDAC1; Neuroprotection; Gene expression; Regulation of gene expression; Cancer research; Immunology; Gene; Biochemistry; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386878,0.0002965519,0.0002405371,0.0001551253,0.0001986291,0.0003741784,0.0001659326,0.0002343853,0.003304616],"category_scores_gemma":[0.0001174493,0.0001063401,0.0002870913,0.0001654957,0.0002448827,0.0001815574,0.0001804339,0.0004034883,0.00150431],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003523279,"about_ca_system_score_gemma":0.0002810554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009494966,"about_ca_topic_score_gemma":0.001452796,"domain_scores_codex":[0.9999167,0.000008502573,0.000003986535,0.00001631923,0.0000294825,0.0000250774],"domain_scores_gemma":[0.999962,0.000004606299,0.0000108395,0.000005612774,0.00000768453,0.000009356037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003444568,0.00003209869,0.000677339,0.0001000986,0.00001908911,0.0001116662,0.00002138821,0.0002888332,0.991376,0.0008524593,0.001035519,0.005140993],"study_design_scores_gemma":[0.00004874949,0.00009644992,0.008537295,0.00001449304,0.000017987,0.0002168456,0.00003339243,0.003235745,0.9771892,0.001014553,0.00958703,0.000008335785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385321,0.0105306,0.02475614,0.001487539,0.0004812378,0.00005043809,0.002964438,0.000981395,0.02021618],"genre_scores_gemma":[0.9824325,0.002364787,0.00435517,0.0001263188,0.00005176467,0.00002251611,0.001290795,0.0001332291,0.009222956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003304616,"threshold_uncertainty_score":0.01105511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755872369613539,"score_gpt":0.2543965254283044,"score_spread":0.2268378017321691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}