{"id":"W4295876078","doi":"10.1101/2022.09.09.507324","title":"The imprinted <i>Mir483</i> is a growth suppressor and metabolic regulator functioning through IGF1","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Japan Society for the Promotion of Science; Cambridge Institute for Medical Research, University of Cambridge; Biotechnology and Biological Sciences Research Council; Medical Research Council; Directorate for Biological Sciences; Cancer Research UK; Anatomical Society; Francis Crick Institute; Uehara Memorial Foundation","keywords":"Genomic imprinting; Psychological repression; Biology; Transgene; microRNA; Imprinting (psychology); Regulator; Suppressor; Endocrinology; Growth factor; Gene expression; Gene; Cell biology; Phenotype; Promoter; Internal medicine; Genetics; Receptor; DNA methylation; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006928847,0.0002865515,0.000116078,0.0001962524,0.000160168,0.0002366621,0.0001569107,0.0002209135,0.001808601],"category_scores_gemma":[0.00007644666,0.0000996477,0.0001629968,0.00008771436,0.0002838062,0.00008868173,0.000193994,0.0003234158,0.0006300681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000198621,"about_ca_system_score_gemma":0.0001279164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003876231,"about_ca_topic_score_gemma":0.0003712923,"domain_scores_codex":[0.9999434,0.000007160389,0.000003335729,0.00001618946,0.00001924163,0.00001075612],"domain_scores_gemma":[0.9999481,0.000006492501,0.00002368274,0.00000490718,0.000003222658,0.00001347351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006691411,0.000003976269,0.0006579543,0.00001331325,0.000003291885,0.0002063489,0.000007166376,0.00005608067,0.9965811,0.0003710186,0.0001077877,0.001925013],"study_design_scores_gemma":[0.00001206555,0.00005464995,0.007583044,0.000004678492,0.00001063708,0.001896795,0.00001515015,0.001195245,0.9816742,0.0002783515,0.007270973,0.000004222286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9703401,0.00108395,0.02040391,0.000345399,0.00009108157,0.00001728521,0.001205885,0.0007387102,0.005773745],"genre_scores_gemma":[0.9898337,0.0003108034,0.00446419,0.00005290532,0.0000145484,0.00001363852,0.0005546014,0.00009983287,0.004655822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001808601,"threshold_uncertainty_score":0.006050408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009018086399011983,"score_gpt":0.2124851755388098,"score_spread":0.2034670891397978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}