{"id":"W4295897144","doi":"10.48550/arxiv.1506.01731","title":"Predictable patterns of CTL escape and reversion across host populations\\n and viral subtypes in HIV-1 evolution","year":2015,"lang":"","type":"preprint","venue":"arXiv (Cornell University)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Reversion; CTL*; Biology; Population; Host (biology); Genetic Fitness; Mutation; Genetics; Point mutation; Virus; Viral evolution; Virology; Mutation rate; Epitope; Cytotoxic T cell; Phenotype; Antibody; Biological evolution; RNA; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007146744,0.0001408769,0.0002055381,0.000452154,0.0003525517,0.0005606629,0.0002394603,0.0003056612,0.0006617129],"category_scores_gemma":[0.001608924,0.0001598261,0.0001799736,0.0003255497,0.0005555501,0.0002528476,0.0004087451,0.0003145006,0.0001322639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003926816,"about_ca_system_score_gemma":0.0002739191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004646069,"about_ca_topic_score_gemma":0.01060206,"domain_scores_codex":[0.999692,0.0000659693,0.00001558241,0.0001125618,0.00005880416,0.00005521054],"domain_scores_gemma":[0.9991683,0.0002934831,0.000204423,0.000159912,0.0001205843,0.00005345102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002816207,0.00005220377,0.860177,0.00003422823,0.0001292841,0.0001211848,0.001201907,0.002454154,0.1172785,0.0006251889,0.0001240099,0.0175207],"study_design_scores_gemma":[0.00000350547,0.00008400789,0.992837,0.000003793839,0.00001999824,0.0001596735,0.000392834,0.002127378,0.003895057,0.0001944344,0.00027105,0.00001129993],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999252,0.00005445271,0.0003422317,0.000006497653,6.645529e-7,0.000002807192,0.00004752862,0.000005940468,0.0002877583],"genre_scores_gemma":[0.9993957,0.00003311608,0.0003184899,0.000008133513,7.10107e-7,0.000004312197,0.0001287881,0.000004698678,0.0001059835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004646069,"threshold_uncertainty_score":0.009238064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05315680470445825,"score_gpt":0.221253447709657,"score_spread":0.1680966430051987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}