{"id":"W4295907188","doi":"10.1172/jci152961","title":"Haploinsufficiency of CYP8B1 associates with increased insulin sensitivity in humans","year":2022,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Biomedical Research Council; National Medical Research Council; Medical Research Council; Public Health England","keywords":"Internal medicine; Insulin; Endocrinology; Insulin resistance; Insulin receptor; Biology; Chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001509206,0.0004662928,0.0003371343,0.0007921208,0.0003319438,0.000299284,0.0001257168,0.0003526719,0.002983155],"category_scores_gemma":[0.0003405543,0.0001606389,0.0001979306,0.0005297455,0.0002976499,0.00009331503,0.0002018521,0.0003072883,0.0002950204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000120045,"about_ca_system_score_gemma":0.00006543562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005700492,"about_ca_topic_score_gemma":0.0003843646,"domain_scores_codex":[0.9998308,0.00003135288,0.00001628341,0.00007560012,0.00003180543,0.00001406645],"domain_scores_gemma":[0.9998218,0.0000265594,0.00008339598,0.00001775036,0.00001586861,0.00003458947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004252524,0.0002329727,0.5759215,0.000187236,0.0005714545,0.01135355,0.0003641678,0.0003179635,0.3630278,0.0007458886,0.002297289,0.04072757],"study_design_scores_gemma":[0.0001030053,0.0005491035,0.9409522,0.0000424393,0.0003016018,0.03228312,0.0001249302,0.0007919275,0.01750536,0.0005602598,0.006761848,0.00002407981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953243,0.001646245,0.001285484,0.0001532404,0.00002691483,0.00001131686,0.0004380744,0.00005747993,0.001056993],"genre_scores_gemma":[0.9981182,0.0003803468,0.0005632828,0.00006135519,0.00002143025,0.000009790118,0.0003163731,0.00002152747,0.000507793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002983155,"threshold_uncertainty_score":0.009979665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04525997567972073,"score_gpt":0.3302166033511524,"score_spread":0.2849566276714317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}