{"id":"W4295941831","doi":"10.1158/1557-3265.sarcomas22-pr005","title":"Abstract PR005: PRC2 inactivating mutations amplify cell death in response to DNMT1-targeted therapy through enhanced viral mimicry in malignant peripheral nerve sheath tumor","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"PRC2; Cancer research; Biology; Context (archaeology); EZH2; Cancer; Epigenetics; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000188023,0.000344505,0.0003117123,0.0002361505,0.0001291521,0.0002999722,0.0002503144,0.0002936426,0.00317479],"category_scores_gemma":[0.0001196099,0.0001161667,0.0002272227,0.0001688133,0.0002259235,0.0002088699,0.0002006486,0.0008479381,0.0005555676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003928001,"about_ca_system_score_gemma":0.0002278522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009054038,"about_ca_topic_score_gemma":0.0009013793,"domain_scores_codex":[0.9998218,0.00002131315,0.00001699346,0.00003960079,0.00006386075,0.00003630402],"domain_scores_gemma":[0.9999274,0.00001379073,0.00001858095,0.000009821062,0.000007892062,0.00002256255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001586547,0.00006357852,0.0001249411,0.0000317847,0.000006847163,0.00003413508,0.00001117936,0.0001162159,0.9966904,0.0001627217,0.0001710709,0.002428507],"study_design_scores_gemma":[0.00002623383,0.0007707801,0.001119963,0.000002432744,0.00001684965,0.0001761396,0.000009118411,0.00118925,0.9943988,0.0000296402,0.002258269,0.00000265409],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986668,0.001449679,0.005131622,0.0002136104,0.0000942394,0.0001451419,0.00127905,0.0004053057,0.004613462],"genre_scores_gemma":[0.9915105,0.0003732462,0.002289931,0.00005778102,0.000008671499,0.00007023757,0.0008542794,0.00003268451,0.004802845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00317479,"threshold_uncertainty_score":0.01062071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1878447620197086,"score_gpt":0.5002895845280105,"score_spread":0.312444822508302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}