{"id":"W4295942126","doi":"10.1158/1557-3265.sarcomas22-a020","title":"Abstract A020: Combined inhibition of SHP2 and CDK4/6 is active in preclinical models of NF1-associated malignant peripheral nerve sheath tumor","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; MAPK/ERK pathway; Kinase; CDKN2A; Cell growth; Cyclin-dependent kinase; Cell cycle; Biology; Medicine; Cell biology; Cancer; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003914607,0.0008841344,0.0005440294,0.0006469249,0.0002926513,0.0003490424,0.0005308993,0.0005069777,0.003116173],"category_scores_gemma":[0.0001381618,0.0002170685,0.0004449335,0.0003506458,0.0003595688,0.0003978609,0.0001521093,0.00167293,0.0006318258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004305731,"about_ca_system_score_gemma":0.0007138501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001246271,"about_ca_topic_score_gemma":0.002522524,"domain_scores_codex":[0.9997924,0.00003664019,0.00001633084,0.00003573293,0.00006147593,0.00005742167],"domain_scores_gemma":[0.9998353,0.00001539628,0.00003401293,0.00001938753,0.00002119316,0.00007472617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008964051,0.00626198,0.0005091131,0.0003787378,0.0001215181,0.0001827281,0.00007461602,0.001005181,0.9664048,0.0003661144,0.001735033,0.01399613],"study_design_scores_gemma":[0.002084636,0.05101721,0.005269114,0.00003568143,0.0001745726,0.000400695,0.00008936482,0.003040105,0.9304568,0.0001706269,0.007239583,0.00002152349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988981,0.002781754,0.00171756,0.0002928491,0.0002019804,0.0003161556,0.001609127,0.0003264046,0.003773269],"genre_scores_gemma":[0.9850259,0.002058906,0.002530494,0.00009599383,0.00004690284,0.0007003315,0.002414113,0.00003634602,0.007091066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003116173,"threshold_uncertainty_score":0.01042461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2322144808109041,"score_gpt":0.4709232120284662,"score_spread":0.2387087312175621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}