{"id":"W4295942215","doi":"10.1158/1557-3265.sarcomas22-a016","title":"Abstract A016: Selective delivery of fibroblast activation protein conjugated dual phosphoinositide 3-kinase–AKT Kinase-mTOR inhibitor associated with decreased tumor proliferation and on-target toxicity in high-grade soft-tissue sarcomas","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fibroblast activation protein, alpha; PI3K/AKT/mTOR pathway; Protein kinase B; HT1080; Cancer research; Fibrosarcoma; Flow cytometry; Biology; Cell growth; Fibroblast; Cell culture; Molecular biology; Medicine; Cancer; Pathology; Phosphorylation; Cell biology; Signal transduction; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009044325,0.0002928824,0.0001690656,0.0001554383,0.00007591845,0.0002018663,0.0001653416,0.0002576556,0.002211183],"category_scores_gemma":[0.00006648585,0.00009516667,0.0001990734,0.0001143647,0.0001054323,0.0001368905,0.00008487196,0.0003555688,0.0005185478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001439556,"about_ca_system_score_gemma":0.0001654193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004891931,"about_ca_topic_score_gemma":0.0003810897,"domain_scores_codex":[0.999935,0.000008066145,0.000006671628,0.00001546802,0.00002102107,0.00001371878],"domain_scores_gemma":[0.9999641,0.000005154434,0.000009571036,0.000002912197,0.0000055295,0.00001283051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003723222,0.000122916,0.00006011845,0.00005401372,0.000004200818,0.00004845209,0.000007134474,0.0000519649,0.9970971,0.00005101763,0.0001671545,0.001963651],"study_design_scores_gemma":[0.00009182811,0.002554118,0.001767986,0.000008554404,0.00001829325,0.0004284725,0.00001258723,0.0008502583,0.9918881,0.00002034355,0.002354084,0.000005194068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935045,0.001158304,0.001673911,0.00008713995,0.00008711444,0.00004119192,0.0004123948,0.000111448,0.002923748],"genre_scores_gemma":[0.9893707,0.0008057034,0.002521414,0.00006109121,0.00001784067,0.00006276622,0.000927553,0.00002500645,0.006207895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002211183,"threshold_uncertainty_score":0.007397175,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05381510034112087,"score_gpt":0.3746805325944472,"score_spread":0.3208654322533264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}