{"id":"W4295948384","doi":"10.1016/j.molcel.2022.08.027","title":"Control of ribosomal RNA synthesis by hematopoietic transcription factors","year":2022,"lang":"en","type":"article","venue":"Molecular Cell","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of General Medical Sciences; National Cancer Institute; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; American Heart Association; Damon Runyon Cancer Research Foundation; Canadian Institutes of Health Research; American Society of Hematology; American Cancer Society; Alex's Lemonade Stand Foundation for Childhood Cancer; Marsden Fund; Cancer Prevention and Research Institute of Texas","keywords":"Biology; Ribosomal RNA; RNA polymerase I; Transcription (linguistics); Transcription factor; RNA polymerase II; Genetics; General transcription factor; RNA; Cell biology; Computational biology; Promoter; Gene; Gene expression; RNA polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002380037,0.0002600974,0.0001285197,0.000355339,0.0002657092,0.0004811777,0.0002531214,0.0001836369,0.001096418],"category_scores_gemma":[0.0001859252,0.0001570344,0.000138993,0.0001969629,0.0003133337,0.0002071834,0.0002052011,0.0003264906,0.0003203029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006138948,"about_ca_system_score_gemma":0.0002318632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001381294,"about_ca_topic_score_gemma":0.00325625,"domain_scores_codex":[0.9998759,0.00002646821,0.000005990935,0.00002868295,0.00002530614,0.00003773324],"domain_scores_gemma":[0.999897,0.00002867376,0.00002347289,0.00001317329,0.00001353141,0.00002402452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001913502,0.000007618753,0.0003886261,0.00002299135,0.000003631756,0.00006329986,0.00002887653,0.0001529287,0.9910066,0.002477048,0.000120855,0.005536197],"study_design_scores_gemma":[0.00001080851,0.00006119286,0.005290934,0.000005735747,0.0000053555,0.00009273957,0.00003124245,0.001121895,0.9896644,0.000452066,0.003259103,0.000004576802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702896,0.01006183,0.008878502,0.0003570854,0.00005115299,0.00002605909,0.0003028425,0.0002976965,0.009735238],"genre_scores_gemma":[0.9936991,0.00106483,0.002139872,0.00003661762,0.00001767402,0.000007182915,0.0001338161,0.00003161577,0.002869257],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381294,"threshold_uncertainty_score":0.004454136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005135054712384612,"score_gpt":0.1950514440413585,"score_spread":0.1899163893289738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}