{"id":"W4295952011","doi":"10.1016/j.redox.2022.102481","title":"Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice","year":2022,"lang":"en","type":"article","venue":"Redox Biology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Xuzhou Science and Technology Program; Wenzhou Municipal Science and Technology Bureau; National Natural Science Foundation of China","keywords":"Tauroursodeoxycholic acid; Metformin; Gut flora; Endocrinology; Internal medicine; Insulin resistance; Oxidative stress; Type 2 diabetes; Metabolic syndrome; Biology; Insulin; Diabetes mellitus; Unfolded protein response; Medicine; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533213,0.0005287404,0.0004110622,0.0008013124,0.0002892094,0.0004016835,0.0002753946,0.0004972063,0.001921188],"category_scores_gemma":[0.0001510439,0.0003112674,0.0006031276,0.0003129283,0.000358782,0.0004637946,0.0003319751,0.001114671,0.0004040507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003803261,"about_ca_system_score_gemma":0.0003417624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000601093,"about_ca_topic_score_gemma":0.0009819644,"domain_scores_codex":[0.9998032,0.00003396874,0.00002316683,0.00005013068,0.00004309887,0.00004636241],"domain_scores_gemma":[0.99986,0.000006127354,0.00004520246,0.00001676645,0.00001389627,0.00005796847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001213281,0.00007818061,0.0006004674,0.0000626884,0.00001588775,0.00007236795,0.00001947357,0.00005497148,0.9955095,0.0002464036,0.00006849948,0.002058276],"study_design_scores_gemma":[0.0001709688,0.0009822303,0.01990739,0.00003248134,0.00008645597,0.0002396858,0.000091161,0.001720408,0.9705299,0.0003736325,0.005849787,0.00001588137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863202,0.003400788,0.005952019,0.000584346,0.0001564254,0.00005931025,0.001097906,0.000248071,0.002181007],"genre_scores_gemma":[0.9866263,0.002545164,0.00367625,0.0002401381,0.00003106678,0.0001604732,0.001055382,0.00006191407,0.005603278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001921188,"threshold_uncertainty_score":0.00642699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007096670207006988,"score_gpt":0.2771533683495843,"score_spread":0.2700566981425773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}