{"id":"W4296007697","doi":"10.1016/j.annonc.2022.07.775","title":"651O Pembrolizumab (pembro) + carboplatin (carbo) + paclitaxel (pacli) as first-line (1L) therapy in recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): Phase VI KEYNOTE-B10 study","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dr. H. Bliss Murphy Cancer Centre; Kingston General Hospital; Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Pembrolizumab; Carboplatin; Internal medicine; Clinical trial; Oncology; Head and neck squamous-cell carcinoma; Phases of clinical research; Surgery; Head and neck cancer; Radiation therapy; Cancer; Chemotherapy; Cisplatin; Adverse effect; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001019667,0.0009573764,0.001516921,0.0003255659,0.000361953,0.0009664265,0.0007767554,0.0007560408,0.00554279],"category_scores_gemma":[0.000338702,0.0004586077,0.001131746,0.0003689213,0.0005062582,0.0006266996,0.0003527919,0.002571064,0.001540056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001108442,"about_ca_system_score_gemma":0.001583833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002874508,"about_ca_topic_score_gemma":0.01030728,"domain_scores_codex":[0.9997328,0.00009036871,0.00001057183,0.0000606136,0.00002611104,0.0000795558],"domain_scores_gemma":[0.9997217,0.00003111499,0.00003452139,0.00002019576,0.00001789877,0.0001745147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6104837,0.1027807,0.009129904,0.002377707,0.002499885,0.0001546964,0.0002610891,0.002206309,0.05565773,0.0003967693,0.01104533,0.2030061],"study_design_scores_gemma":[0.4697736,0.4955721,0.01832184,0.0001375828,0.001536721,0.000254465,0.000116862,0.0008431628,0.005108633,0.0001912275,0.008108517,0.00003540647],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852821,0.004855839,0.0003792991,0.000575945,0.0002453304,0.002018676,0.002540672,0.0001200264,0.003982129],"genre_scores_gemma":[0.9724892,0.00763378,0.001932858,0.001976981,0.0002225856,0.00175471,0.005861356,0.00005795191,0.008070699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00554279,"threshold_uncertainty_score":0.01854247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08756686997280383,"score_gpt":0.3949093965393589,"score_spread":0.3073425265665551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}