{"id":"W4296017074","doi":"10.3390/molecules27185923","title":"Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach","year":2022,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"King Abdulaziz University","keywords":"Cytotoxicity; Conjugate; Chemistry; Combinatorial chemistry; Molecule; Virology; Stereochemistry; Biology; Biochemistry; Organic chemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002094179,0.000531419,0.0005675582,0.0002856936,0.0002321796,0.0002791518,0.0003038114,0.0004403023,0.002594322],"category_scores_gemma":[0.0002508271,0.0002853081,0.0004091076,0.0002660618,0.0001478052,0.0003841748,0.0002798545,0.0005301329,0.0009355306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003683645,"about_ca_system_score_gemma":0.0002744589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000255985,"about_ca_topic_score_gemma":0.000624027,"domain_scores_codex":[0.9998865,0.00002703907,0.000008289708,0.00003048463,0.00002265205,0.00002501347],"domain_scores_gemma":[0.9999471,0.00001197619,0.00001645115,0.000005820156,0.00001011739,0.000008567591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494264,0.0001219742,0.0002324103,0.0003707966,0.00004431454,0.0002873595,0.0000563719,0.004658422,0.9738706,0.002225552,0.0003832518,0.01759944],"study_design_scores_gemma":[0.00007923869,0.001783402,0.0004438277,0.00002113101,0.00007881039,0.0003591616,0.00002941583,0.005532071,0.9745049,0.000441373,0.01668975,0.00003702755],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8965676,0.009287906,0.07436177,0.0005557941,0.0002189424,0.0007782516,0.0008105596,0.0005985222,0.01682056],"genre_scores_gemma":[0.923768,0.004487795,0.06433839,0.0002539626,0.00004335025,0.000460061,0.0005110137,0.0000575642,0.006079852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002594322,"threshold_uncertainty_score":0.008678854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04037250869879772,"score_gpt":0.2669286288078218,"score_spread":0.226556120109024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}