{"id":"W4296017122","doi":"10.1021/acsomega.2c04702","title":"Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R","year":2022,"lang":"en","type":"article","venue":"ACS Omega","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation; Van Andel Research Institute","keywords":"Ornithine decarboxylase; Ornithine decarboxylase antizyme; Enzyme; Biochemistry; Chemistry; Pyridoxal; Phosphorylation; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001538205,0.0001037205,0.0001485098,0.00002221749,0.000133234,0.000009929917,0.0001705142,0.00005685019,0.00002845577],"category_scores_gemma":[0.0002578779,0.00009989032,0.00003036004,0.0001665724,0.0001221535,0.000005318856,0.0002377008,0.0001212343,4.137212e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001236389,"about_ca_system_score_gemma":0.00004162216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006429345,"about_ca_topic_score_gemma":0.00007154076,"domain_scores_codex":[0.9992512,0.0001287673,0.0001349205,0.0002415379,0.0001082114,0.0001353222],"domain_scores_gemma":[0.9994359,0.00004758625,0.00008232909,0.0003427074,0.00002828532,0.00006316196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007250405,0.0003496025,0.001266466,0.00001536878,0.00005776371,0.000001123183,0.0002953249,0.00003968427,0.992323,0.0001755257,0.0002603038,0.005143336],"study_design_scores_gemma":[0.001559101,0.0007474234,0.04636841,0.000004702295,0.0001306805,0.00006137765,0.000338235,0.0008122815,0.9390913,0.002089049,0.008347197,0.000450308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989061,0.0002001636,0.0001220237,0.00009393763,0.00004634786,0.000149175,0.0004043381,0.00001048295,0.00006738987],"genre_scores_gemma":[0.9992939,0.00001831071,0.0001544569,0.00007893105,0.00004879679,0.00002999389,0.0002540468,0.00001297291,0.0001086064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05323176,"threshold_uncertainty_score":0.4073409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007369768485812667,"score_gpt":0.240786543039756,"score_spread":0.2334167745539433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}