{"id":"W4296017122","doi":"10.1021/acsomega.2c04702","title":"Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R","year":2022,"lang":"en","type":"article","venue":"ACS Omega","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation; Van Andel Research Institute","keywords":"Ornithine decarboxylase; Ornithine decarboxylase antizyme; Enzyme; Biochemistry; Chemistry; Pyridoxal; Phosphorylation; Biology; Molecular biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009386353,0.0003882302,0.000349661,0.0002073184,0.000193359,0.0002836082,0.0005831114,0.0006617873,0.0009371655],"category_scores_gemma":[0.0002933555,0.0001347467,0.0003301706,0.0003211358,0.0002727281,0.0001382951,0.0002191153,0.0007971131,0.0003915857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005532862,"about_ca_system_score_gemma":0.0001740585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004166442,"about_ca_topic_score_gemma":0.00145119,"domain_scores_codex":[0.9998883,0.00001300142,0.000008479068,0.00002936799,0.00003574515,0.00002512087],"domain_scores_gemma":[0.9998797,0.00001690879,0.00004410167,0.000008396162,0.0000181691,0.0000327009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007563067,0.0001732612,0.004200817,0.0001120959,0.00005902983,0.002871569,0.0001065686,0.002326768,0.9847305,0.0004158507,0.0005904917,0.003656802],"study_design_scores_gemma":[0.0006152996,0.00204823,0.1342666,0.00006760761,0.0002672791,0.01064205,0.000633187,0.04147276,0.7841911,0.0007513017,0.02486697,0.0001775195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978501,0.0005217374,0.00043252,0.000118746,0.00001793214,0.00000741516,0.0005078673,0.0000218747,0.0005217658],"genre_scores_gemma":[0.9939929,0.0004002774,0.001103427,0.00008191549,0.00001518444,0.00001002708,0.002531457,0.00002557841,0.001839299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004166442,"threshold_uncertainty_score":0.00828439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007369768485812667,"score_gpt":0.240786543039756,"score_spread":0.2334167745539433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}