{"id":"W4296020023","doi":"10.1016/j.annonc.2022.07.145","title":"113P Pembrolizumab in microsatellite instability-high (MSI-H)/mismatch repair deficient (dMMR) advanced solid tumors: An update of the phase II KEYNOTE-158 trial","year":2022,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Microsatellite instability; Oncology; Internal medicine; DNA mismatch repair; Cancer; Immunotherapy; Colorectal cancer; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002217356,0.0009283818,0.002288509,0.000274463,0.0003039875,0.001324072,0.0005911898,0.0009766263,0.005104657],"category_scores_gemma":[0.001751862,0.0003133296,0.001661404,0.0004640005,0.0003916999,0.00122953,0.0004278941,0.004305941,0.001217912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009699996,"about_ca_system_score_gemma":0.0008665592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009019211,"about_ca_topic_score_gemma":0.003893637,"domain_scores_codex":[0.9995359,0.0002143326,0.00002832034,0.00006028613,0.00007751367,0.00008350048],"domain_scores_gemma":[0.999469,0.0001916499,0.0001036586,0.00003867595,0.0000633932,0.000133682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3571517,0.003490019,0.003816033,0.007293741,0.006053959,0.000255037,0.0002386308,0.002516392,0.01375627,0.002198653,0.0548605,0.5483691],"study_design_scores_gemma":[0.8255972,0.06802826,0.01429141,0.001666528,0.004789353,0.0005920819,0.000140372,0.001749824,0.00235613,0.002988264,0.0777111,0.00008943909],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7172452,0.1896335,0.004892997,0.01800995,0.00436087,0.005040146,0.01558373,0.0007168618,0.04451673],"genre_scores_gemma":[0.8433968,0.08823123,0.008472324,0.01604476,0.001394226,0.004820861,0.0137241,0.0002760027,0.02363978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005104657,"threshold_uncertainty_score":0.01707679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05300824291177602,"score_gpt":0.3893450993631417,"score_spread":0.3363368564513657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}