{"id":"W4296025748","doi":"10.1093/ibd/izac188","title":"Decreased Infliximab Concentrations in Patients With Inflammatory Bowel Disease Who Carry a Variable Number Tandem Repeat Polymorphism in the Neonatal Fc Receptor or Variant<i>HLADQA1*05G&amp;gt;A</i>Genotype","year":2022,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Academic Medical Organization of Southwestern Ontario","keywords":"Infliximab; Interquartile range; Medicine; Gastroenterology; Inflammatory bowel disease; Internal medicine; Genotype; Trough level; Variable number tandem repeat; Tumor necrosis factor alpha; Disease; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003343777,0.0002458085,0.0003934323,0.0003264084,0.0002899841,0.000518841,0.0002258251,0.0004794179,0.001613195],"category_scores_gemma":[0.001350505,0.0001847382,0.0002228373,0.0005322645,0.0002033932,0.0002212393,0.0001705271,0.0004259772,0.0002084704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002225256,"about_ca_system_score_gemma":0.0001379624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001516874,"about_ca_topic_score_gemma":0.001783813,"domain_scores_codex":[0.9996995,0.00007527122,0.00003429192,0.0001007386,0.00005057207,0.00003966008],"domain_scores_gemma":[0.9992544,0.0001445332,0.0004060375,0.00004291906,0.00005713617,0.00009488778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003976137,0.0000348201,0.9964552,0.00001098372,0.00004629913,0.0001244855,0.00007195852,0.00002669925,0.001686706,0.000008549601,0.00005557384,0.001081022],"study_design_scores_gemma":[0.00002294307,0.0002659914,0.9985065,0.00000429647,0.00003999306,0.000675823,0.00007731195,0.0001048619,0.0001746359,0.00001372821,0.0001110939,0.000002723049],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999645,0.000142951,0.00003830329,0.00001457835,0.000003126481,0.000001750866,0.00005106567,0.00000145256,0.0001017428],"genre_scores_gemma":[0.9997597,0.00003066521,0.00005222376,0.00002461914,0.000005070491,0.000002640769,0.00006674432,8.463707e-7,0.00005750122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001613195,"threshold_uncertainty_score":0.005396664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005516047173362734,"score_gpt":0.2004944079018515,"score_spread":0.1949783607284888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}