{"id":"W4296025748","doi":"10.1093/ibd/izac188","title":"Decreased Infliximab Concentrations in Patients With Inflammatory Bowel Disease Who Carry a Variable Number Tandem Repeat Polymorphism in the Neonatal Fc Receptor or Variant<i>HLADQA1*05G&amp;gt;A</i>Genotype","year":2022,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Academic Medical Organization of Southwestern Ontario","keywords":"Infliximab; Interquartile range; Medicine; Gastroenterology; Inflammatory bowel disease; Internal medicine; Genotype; Trough level; Variable number tandem repeat; Tumor necrosis factor alpha; Disease; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005670483,0.0006285537,0.0005301949,0.0002825236,0.00116452,0.0001065633,0.001042282,0.0002142178,0.004459956],"category_scores_gemma":[0.0003594381,0.0005009927,0.0002012725,0.0007239667,0.0005937259,0.0006011456,0.0003204879,0.0008979007,0.0002676998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003347992,"about_ca_system_score_gemma":0.001557066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002255583,"about_ca_topic_score_gemma":0.0001219185,"domain_scores_codex":[0.9953045,0.001315657,0.001046805,0.0008456093,0.0004069523,0.001080443],"domain_scores_gemma":[0.9977718,0.0004189367,0.0004151292,0.00115814,0.0001451213,0.0000908818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0113789,0.002152721,0.9719859,0.0001253434,0.0002578828,0.0005190524,0.005002329,0.00217866,0.0005821395,0.002405363,0.00248716,0.0009245925],"study_design_scores_gemma":[0.009835332,0.0001883996,0.9313695,0.0001950521,0.0001819941,0.00005063283,0.001745673,0.00004719077,0.00002774066,0.000193291,0.05525429,0.0009109294],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987655,0.007976555,0.00003310732,0.0001963683,0.0007057376,0.001643729,0.001176563,0.0001715447,0.0004414358],"genre_scores_gemma":[0.9946285,0.00007035671,0.00002072809,0.0009067014,0.00002282357,0.0009627831,0.002391957,0.00007930533,0.0009168668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05276713,"threshold_uncertainty_score":0.9997442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005516047173362734,"score_gpt":0.2004944079018515,"score_spread":0.1949783607284888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}