{"id":"W4296027240","doi":"10.1158/2159-8290.cd-21-0865","title":"Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Terry Fox Research Institute; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Cancer Institute; Generalitat de Catalunya; Dr. Herbert and Nicole Wertheim Family Foundation; Breast Cancer Research Foundation","keywords":"Epigenetics; Biology; Breast cancer; Lineage (genetic); Cancer; Cancer research; Epigenesis; Genetics; Cell biology; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001137328,0.0001840989,0.0001557202,0.000173514,0.0001258057,0.0003023781,0.0001643457,0.0002460298,0.001454239],"category_scores_gemma":[0.0001140919,0.0001130253,0.0001679185,0.00008205591,0.0002220873,0.0001167329,0.000327089,0.000346278,0.0002705421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002836012,"about_ca_system_score_gemma":0.0001818908,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000414889,"about_ca_topic_score_gemma":0.0007730206,"domain_scores_codex":[0.9998468,0.00001715196,0.00001453543,0.00003968696,0.0000458293,0.000035914],"domain_scores_gemma":[0.9999197,0.00001105208,0.00003310116,0.00001275418,0.000007902659,0.00001554966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003847746,0.00001305068,0.0007363054,0.00001956375,0.000005471825,0.00007448877,0.000006063346,0.00006520639,0.9970516,0.000102838,0.00004137259,0.00184553],"study_design_scores_gemma":[0.000008324248,0.0001797041,0.01351964,0.000005756796,0.00002530313,0.0006478141,0.00003330776,0.001317605,0.9814318,0.00009142821,0.002734575,0.000004735384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931654,0.001154093,0.003436817,0.0001363347,0.00002752883,0.00001632602,0.0002924503,0.0001948234,0.001576108],"genre_scores_gemma":[0.9966756,0.0004760406,0.001004956,0.00005419254,0.000005026492,0.000008548606,0.0001872391,0.00001413891,0.001574286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001454239,"threshold_uncertainty_score":0.004864872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112026521973829,"score_gpt":0.2992731074032845,"score_spread":0.2881528421835462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}