{"id":"W4296027240","doi":"10.1158/2159-8290.cd-21-0865","title":"Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Terry Fox Research Institute; Instituto de Salud Carlos III; Canadian Institutes of Health Research; National Cancer Institute; Generalitat de Catalunya; Dr. Herbert and Nicole Wertheim Family Foundation; Breast Cancer Research Foundation","keywords":"Epigenetics; Biology; Breast cancer; Lineage (genetic); Cancer; Cancer research; Epigenesis; Genetics; Cell biology; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009762721,0.0001382755,0.0001546277,0.00003949296,0.00008072474,0.00001939395,0.0001269808,0.0000564073,0.00006487688],"category_scores_gemma":[0.000007424724,0.0001340086,0.00006135026,0.0001016179,0.00007259464,0.000008259607,0.0002055316,0.00009894378,1.70087e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003038136,"about_ca_system_score_gemma":0.0001143395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003104401,"about_ca_topic_score_gemma":0.0001810132,"domain_scores_codex":[0.9991676,0.00003472589,0.0001892421,0.0002975251,0.0001416322,0.0001692368],"domain_scores_gemma":[0.9996167,0.000007886589,0.00007998595,0.0002077724,0.00004022054,0.00004739411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009353914,0.00005918075,0.04214148,0.0001220902,0.00008150108,0.000001410671,0.0001616414,0.005892739,0.9443631,0.00002455041,0.0002413877,0.006817413],"study_design_scores_gemma":[0.0004095092,0.0001140232,0.2636794,0.00004837874,0.00005790807,0.00002462013,0.0001598514,0.0002974442,0.7334501,0.00004218324,0.001466397,0.000250262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848132,0.01242606,0.00163901,0.0002246578,0.0002861394,0.0001708454,0.0003952278,0.000006915888,0.00003800157],"genre_scores_gemma":[0.9971035,0.001982612,0.00006587971,0.00005209781,0.0002236109,0.0001356457,0.00007235667,0.00002357653,0.0003407147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2215379,"threshold_uncertainty_score":0.5464714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112026521973829,"score_gpt":0.2992731074032845,"score_spread":0.2881528421835462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}