{"id":"W4296031587","doi":"10.1038/s41467-022-32701-6","title":"Transcriptional profiling of matched patient biopsies clarifies molecular determinants of enzalutamide-induced lineage plasticity","year":2022,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"National Cancer Institute; Astellas Pharma; University of Michigan Comprehensive Cancer Center; Prostate Cancer Foundation; Astellas Pharma Global Development; National Comprehensive Cancer Network; University of Michigan; National Heart, Lung, and Blood Institute; V Foundation for Cancer Research; U.S. Department of Health and Human Services; Doris Duke Charitable Foundation; Stand Up To Cancer; Rogel Cancer Center, University of Michigan; U.S. Department of Defense","keywords":"Enzalutamide; Transcriptome; Lineage (genetic); Prostate cancer; Biology; Cancer research; Transcription factor; Cancer; Androgen receptor; Bioinformatics; Oncology; Gene; Medicine; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001510184,0.00009211424,0.0002468291,0.0001521932,0.0001866137,0.000003990766,0.0003330654,0.0001084767,0.00004065582],"category_scores_gemma":[0.0001147173,0.00008009039,0.0001068325,0.0003237984,0.0001528839,0.00003645416,0.0002296146,0.0008048421,6.653668e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008387765,"about_ca_system_score_gemma":0.0002484372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000378523,"about_ca_topic_score_gemma":0.00002402238,"domain_scores_codex":[0.998904,0.0001375483,0.0003175749,0.0001286018,0.0003802985,0.0001320069],"domain_scores_gemma":[0.998797,0.0001637916,0.0001341455,0.000613575,0.0002449835,0.00004652181],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003831311,0.0008567648,0.02657118,0.0001488443,0.0001365075,0.00001082573,0.001530156,0.00004744843,0.9668846,0.00241136,0.00003785041,0.0009812925],"study_design_scores_gemma":[0.001222031,0.0005658576,0.02784106,0.0000852096,0.0001279504,0.00002107589,0.001412318,0.001190997,0.9664651,0.00009988891,0.000866136,0.0001023899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992737,0.005199714,0.00002210246,0.0007707878,0.00006253837,0.0004866997,0.0002488225,0.00002082363,0.0004515447],"genre_scores_gemma":[0.9952855,0.0002060673,0.004050502,0.00007242621,0.000007143441,0.0001343464,0.0001923475,0.00001284528,0.00003887566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004993647,"threshold_uncertainty_score":0.3496683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04458063456950315,"score_gpt":0.351183550161108,"score_spread":0.3066029155916048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}