{"id":"W4296034623","doi":"10.1002/cpt.2748","title":"Pharmacogenomic Testing and Depressive Symptom Remission: A Systematic Review and <scp>Meta‐Analysis</scp> of Prospective, Controlled Clinical Trials","year":2022,"lang":"en","type":"review","venue":"Clinical Pharmacology & Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Alberta Children's Hospital; Centre for Addiction and Mental Health; University of Manitoba; Children's Hospital Research Institute of Manitoba; University of Calgary","funders":"","keywords":"Meta-analysis; Pharmacogenomics; Clinical trial; Medicine; MEDLINE; Internal medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03812591,0.002589595,0.01599646,0.005937724,0.0006143888,0.004082924,0.001813983,0.002248593,0.002486027],"category_scores_gemma":[0.07689544,0.001404811,0.03624896,0.008024605,0.001066443,0.001972313,0.001350429,0.001851169,0.0002509441],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002402489,"about_ca_system_score_gemma":0.004134547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005174003,"about_ca_topic_score_gemma":0.01029024,"domain_scores_codex":[0.9652752,0.0209047,0.00786256,0.002424314,0.00300306,0.000530153],"domain_scores_gemma":[0.9393559,0.04806358,0.007868696,0.001977735,0.002430478,0.000303561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.001808544,0.00002080348,0.006538157,0.2807418,0.6964943,0.00008328562,0.00005774888,0.0005336714,0.0001997806,0.0002023687,0.0007374655,0.01258215],"study_design_scores_gemma":[0.0008475091,0.0001934669,0.00494658,0.02874319,0.9628629,0.00007316674,0.0000307858,0.0003521194,0.0001324145,0.0003570938,0.00143736,0.00002346299],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004887618,0.9915568,0.001399904,0.0004762963,0.0002458483,0.0005149861,0.0005981115,0.00004293582,0.0002774259],"genre_scores_gemma":[0.3068372,0.6759624,0.008708542,0.002535954,0.0006822193,0.003141682,0.001666195,0.00007214174,0.0003937249],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.03812591,"threshold_uncertainty_score":0.2016315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6450440072230488,"score_gpt":0.6158629572286234,"score_spread":0.02918104999442539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}