{"id":"W4296035094","doi":"10.1182/blood.2022016571","title":"The von Willebrand factor–binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A","year":2022,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"","keywords":"Pharmacokinetics; Medicine; Pharmacodynamics; Von Willebrand factor; Factor IX; Pharmacology; Tolerability; Coagulopathy; Internal medicine; Gastroenterology; Adverse effect; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002506275,0.0002028401,0.0002957501,0.0001326515,0.000123397,0.0001896903,0.0001115049,0.0001714773,0.0006046549],"category_scores_gemma":[0.0002800654,0.0000642085,0.0001806217,0.0001020792,0.000138479,0.0001463781,0.00009014877,0.0003651059,0.000113938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001401507,"about_ca_system_score_gemma":0.0001489492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002357372,"about_ca_topic_score_gemma":0.0004820914,"domain_scores_codex":[0.9998837,0.00006355847,0.000007165535,0.00001487442,0.00001873235,0.0000120536],"domain_scores_gemma":[0.9998953,0.00002645257,0.0000241476,0.000006322359,0.000005241709,0.0000424733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.1160338,0.01297861,0.02413698,0.0003337399,0.0004458486,0.0009533233,0.0002724446,0.00210816,0.1361618,0.000740332,0.002881267,0.7029537],"study_design_scores_gemma":[0.04901742,0.6770484,0.2099991,0.00006765602,0.0003560968,0.005687346,0.0001539488,0.005187665,0.03370889,0.000496012,0.01821779,0.00005962305],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973305,0.001573387,0.0002600264,0.00007966819,0.00001857856,0.00007112321,0.00004373633,0.00001744697,0.0006054644],"genre_scores_gemma":[0.9982643,0.0007509141,0.0003372784,0.00006692632,0.00002534572,0.00002941408,0.00008888615,0.00000274169,0.0004342299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006046549,"threshold_uncertainty_score":0.002022803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02967570965230623,"score_gpt":0.298548953806393,"score_spread":0.2688732441540868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}