{"id":"W4296077853","doi":"10.11606/d.46.2022.tde-06092022-130610","title":"Modelagem celular>i< in vitro>/i< da Doença de Huntington com ácido 3-nitropropiônico e ácido quinolínico & Avaliação das funções neuroprotetoras da adenosina","year":2022,"lang":"pt","type":"dissertation","venue":"","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Air (Canada)","funders":"","keywords":"Neuroprotection; Medium spiny neuron; Excitotoxicity; Huntingtin; Quinolinic acid; NMDA receptor; Agonist; Huntington's disease; Glutamate receptor; Biology; Pharmacology; Striatum; Cell biology; Molecular biology; Chemistry; Receptor; Biochemistry; Neuroscience; Internal medicine; Dopamine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003913327,0.0007641922,0.0005065012,0.0005454529,0.0003297328,0.0006388044,0.0007987025,0.0009338235,0.003478975],"category_scores_gemma":[0.0001249191,0.0003316101,0.0005722086,0.0003505218,0.0005256016,0.0003674153,0.0004187725,0.001416708,0.002360866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005700347,"about_ca_system_score_gemma":0.0005068654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001465035,"about_ca_topic_score_gemma":0.002002425,"domain_scores_codex":[0.9996027,0.00003658471,0.00003118951,0.0001296056,0.0001317165,0.00006818127],"domain_scores_gemma":[0.9998099,0.00003028116,0.00003930242,0.00004981447,0.00002651694,0.00004423068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001652739,0.0001640902,0.0002256669,0.0001492389,0.00001076337,0.0002881194,0.00007171572,0.0003095964,0.9947348,0.0007482221,0.000368373,0.002764238],"study_design_scores_gemma":[0.00005314321,0.00108919,0.001404053,0.00004276188,0.00007730928,0.0005710885,0.00007174926,0.002291795,0.9704659,0.0002074222,0.02371068,0.00001501036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7729254,0.01103189,0.1595651,0.0008411291,0.001371054,0.002040616,0.01009794,0.003816744,0.03831012],"genre_scores_gemma":[0.8643596,0.007253811,0.07192754,0.0004199465,0.0001181292,0.00236286,0.006885033,0.0002297472,0.04644338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003478975,"threshold_uncertainty_score":0.01163834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0367788194262906,"score_gpt":0.3018246743367118,"score_spread":0.2650458549104212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}