{"id":"W4296120651","doi":"10.1007/s13205-022-03336-7","title":"An in-vivo microfluidic assay reveals cardiac toxicity of heavy metals and the protective effect of metal responsive transcription factor (MTF-1) in Drosophila model","year":2022,"lang":"en","type":"article","venue":"3 Biotech","topic":"Environmental Toxicology and Ecotoxicology","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Toxicity; Cardiotoxicity; Hemolymph; In vivo; Cadmium; Toxicology; Chronic toxicity; Heart rate; Biology; Pharmacology; Chemistry; Internal medicine; Endocrinology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095939,0.0003864596,0.0001296451,0.0002059025,0.0001818618,0.0001546451,0.0003223077,0.0003436091,0.001070378],"category_scores_gemma":[0.0000703028,0.0001835138,0.0003048187,0.00007522073,0.0001878445,0.0001732119,0.000192512,0.0004977947,0.0001905423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000321344,"about_ca_system_score_gemma":0.0002129641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001334886,"about_ca_topic_score_gemma":0.002512943,"domain_scores_codex":[0.9998922,0.000005765577,0.000006802165,0.00004216169,0.00002466325,0.00002833913],"domain_scores_gemma":[0.9999095,0.00001527482,0.00003360497,0.000008781316,0.00001006545,0.0000228214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000175993,0.000008641759,0.00006617369,0.000007642444,0.000001158115,0.00001515244,0.000004739861,0.00002099319,0.9996116,0.00004347967,0.00001895406,0.0001838304],"study_design_scores_gemma":[0.000009520809,0.0001141574,0.002686135,0.000002064045,0.000009820296,0.00005213991,0.0000128352,0.001031555,0.9955906,0.00002884783,0.0004585108,0.000003931219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829912,0.0006638693,0.01309868,0.000184,0.0000946784,0.00005036789,0.0008035623,0.0001588283,0.001954827],"genre_scores_gemma":[0.9806146,0.0005933931,0.01173235,0.0001131245,0.00001689753,0.0001103757,0.0005961788,0.00002753123,0.00619534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334886,"threshold_uncertainty_score":0.003580749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007847234512266,"score_gpt":0.2383573318377643,"score_spread":0.2282788594926417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}