{"id":"W4296120651","doi":"10.1007/s13205-022-03336-7","title":"An in-vivo microfluidic assay reveals cardiac toxicity of heavy metals and the protective effect of metal responsive transcription factor (MTF-1) in Drosophila model","year":2022,"lang":"en","type":"article","venue":"3 Biotech","topic":"Environmental Toxicology and Ecotoxicology","field":"Environmental Science","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Toxicity; Cardiotoxicity; Hemolymph; In vivo; Cadmium; Toxicology; Chronic toxicity; Heart rate; Biology; Pharmacology; Chemistry; Internal medicine; Endocrinology; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002734311,0.0001739246,0.0005413606,0.0001199665,0.000138344,0.000004097147,0.0002463804,0.0001875564,0.0003453348],"category_scores_gemma":[0.00009003563,0.0001355288,0.0001167756,0.0003613362,0.0007835309,0.0001458172,0.0001972729,0.0004346984,0.000002382773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002510908,"about_ca_system_score_gemma":0.00001114778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001932619,"about_ca_topic_score_gemma":0.00007390786,"domain_scores_codex":[0.9964134,0.002333071,0.0003774035,0.0003932249,0.0002333028,0.0002495629],"domain_scores_gemma":[0.9992177,0.0003066588,0.0001520618,0.00027728,0.000002233386,0.00004408256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00150264,0.0001824518,0.007997494,0.0000164037,0.00002586041,0.000003623801,0.001023337,0.001963011,0.9869277,0.00008593226,0.00001959161,0.00025194],"study_design_scores_gemma":[0.001304707,0.001067077,0.02680934,0.000006080014,0.00003284555,0.000006411043,0.0001515901,0.001039433,0.9682627,0.001153107,0.00003828991,0.0001284521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973488,0.0003818955,0.00007600077,0.0002404693,0.00005571277,0.001504611,0.0001479609,0.000008594121,0.000235964],"genre_scores_gemma":[0.9993225,0.0000952892,0.000102496,0.0000927857,0.000004733994,0.0002987549,0.000003406959,0.000012337,0.00006768289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01881184,"threshold_uncertainty_score":0.5526702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007847234512266,"score_gpt":0.2383573318377643,"score_spread":0.2282788594926417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}