{"id":"W4296122525","doi":"10.1158/1557-3265.sarcomas22-b005","title":"Abstract B005: Hypoxic sarcoma spheroid on a chip: Insights into treatment response","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Polytechnique Montréal","funders":"","keywords":"Tirapazamine; Hypoxia (environmental); Cancer research; Tumor hypoxia; Metastasis; Sarcoma; Spheroid; Soft tissue sarcoma; Pathology; Biology; Cell culture; Radiation therapy; Medicine; Cancer; In vitro; Internal medicine; Chemistry; Cytotoxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002324061,0.0003559284,0.0003337942,0.0002077614,0.0001276826,0.0002263252,0.0002862678,0.0005504861,0.002986258],"category_scores_gemma":[0.0002313533,0.0001467855,0.0003232158,0.0001620129,0.0001444495,0.0001510696,0.0001619142,0.000245552,0.0008147625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003961103,"about_ca_system_score_gemma":0.0002551234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001029893,"about_ca_topic_score_gemma":0.001184226,"domain_scores_codex":[0.9998367,0.00001696155,0.000008117793,0.00003753816,0.00007606688,0.00002467974],"domain_scores_gemma":[0.9998653,0.00005971333,0.00001841577,0.00001053635,0.00003217761,0.00001381487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009854054,0.00004663541,0.0004495681,0.0002334367,0.00001479852,0.00005827942,0.00003338529,0.002510218,0.9875675,0.0001414201,0.001546866,0.00729922],"study_design_scores_gemma":[0.00002095564,0.0004572789,0.004285003,0.00001064096,0.0000394159,0.0001151953,0.00003933637,0.02686045,0.9597006,0.0001239134,0.008326492,0.00002064614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8849493,0.005197843,0.0904213,0.001026607,0.00060068,0.0001903029,0.006677546,0.002787866,0.008148585],"genre_scores_gemma":[0.9502358,0.001686558,0.03799819,0.000376883,0.00007146814,0.0002668056,0.003238109,0.00016294,0.005963136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002986258,"threshold_uncertainty_score":0.009990036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1170163582059371,"score_gpt":0.4561327114930263,"score_spread":0.3391163532870892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}