{"id":"W4296125703","doi":"10.1016/j.jhep.2022.09.002","title":"Bepirovirsen/GSK3389404: Antisense or TLR9 agonists?","year":2022,"lang":"es","type":"letter","venue":"Journal of Hepatology","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Quebec Rehabilitation Research Network","funders":"","keywords":"TLR9; Business; Pharmacology; Computational biology; Medicine; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001013744,0.0004336294,0.0007724341,0.000322717,0.0005959402,0.0009335798,0.0004815698,0.01108118,0.008630492],"category_scores_gemma":[0.00340449,0.0002022515,0.0005789892,0.0002471808,0.0008432451,0.001057829,0.0004639912,0.006059225,0.004933749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001075931,"about_ca_system_score_gemma":0.0007924805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004909353,"about_ca_topic_score_gemma":0.000989125,"domain_scores_codex":[0.9996262,0.0001383668,0.00004486676,0.00003726512,0.00007854689,0.00007472072],"domain_scores_gemma":[0.9990989,0.0004568801,0.0001031091,0.00003660053,0.00006978745,0.0002346853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00234374,0.0002621249,0.001994846,0.0003800375,0.0000818382,0.0106242,0.00007895841,0.0002104766,0.00318378,0.01058035,0.8200658,0.1501938],"study_design_scores_gemma":[0.00251598,0.001110736,0.002600948,0.0005175813,0.0001118243,0.01053741,0.0001645925,0.0004896419,0.002163754,0.01601547,0.9637182,0.00005381791],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.005545016,0.01345581,0.0003245645,0.9451567,0.01876419,0.00003463996,0.0001716803,0.00007980822,0.01646756],"genre_scores_gemma":[0.06723148,0.01782212,0.00108627,0.7836187,0.09687448,0.0001740076,0.0002060887,0.00003909879,0.03294774],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01108118,"threshold_uncertainty_score":0.02887183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03918400191811133,"score_gpt":0.3163265715911373,"score_spread":0.277142569673026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}