{"id":"W4296129042","doi":"10.1101/2022.09.13.507804","title":"Derepression masquerades as activation in a pentameric ligand-gated ion channel","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Derepression; Agonist; Chemistry; Protein subunit; Partial agonist; Ion channel; Ligand-gated ion channel; Biophysics; Receptor; Ligand (biochemistry); Cell biology; Psychological repression; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122544,0.0001171689,0.0002333594,0.00008039438,0.0001428836,0.0005437179,0.0001732634,0.0002630311,0.001163568],"category_scores_gemma":[0.0001938077,0.00009590019,0.0001552727,0.00007938058,0.0004438072,0.0004073593,0.0002480139,0.0006587856,0.0004305668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001906042,"about_ca_system_score_gemma":0.0001001841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007140757,"about_ca_topic_score_gemma":0.0001283503,"domain_scores_codex":[0.9998931,0.0000123655,0.000008108719,0.00003715277,0.00002496897,0.00002433095],"domain_scores_gemma":[0.9998628,0.00002756995,0.00003072499,0.00003149738,0.000009676726,0.00003773073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008301123,0.00001658157,0.000347416,0.00002007694,0.000004026953,0.0001929719,0.00006818458,0.0001588196,0.9951882,0.002362573,0.00008124905,0.00147685],"study_design_scores_gemma":[0.0000336422,0.0003606933,0.01251893,0.00001418944,0.00002170133,0.001898568,0.0002047062,0.01297654,0.9589771,0.00519746,0.007769184,0.00002728854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876288,0.0003960575,0.008432873,0.000215969,0.00004094436,0.00001008337,0.00008590115,0.0002157216,0.002973583],"genre_scores_gemma":[0.9970772,0.0001389278,0.001405435,0.00007477332,0.000009585235,0.00000943689,0.00008209823,0.00003040304,0.001172094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163568,"threshold_uncertainty_score":0.003892541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01155769374652771,"score_gpt":0.2479808989545834,"score_spread":0.2364232052080557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}