{"id":"W4296130403","doi":"10.1158/1557-3265.sarcomas22-ia011","title":"Abstract IA011: Identifying tumor-restricted target antigens for adoptive cellular immunotherapy to treat Ewing Sarcoma using multi-omic discovery platforms","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Major histocompatibility complex; Immunotherapy; Antigen; Biology; Transcriptome; Cancer research; Sarcoma; Computational biology; Immunology; Medicine; Immune system; Gene; Gene expression; Genetics; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004261421,0.0006392584,0.0005586037,0.000787684,0.0002860157,0.001098471,0.0003312862,0.0003742433,0.002092942],"category_scores_gemma":[0.0002510556,0.0001920119,0.0005263606,0.0007122872,0.0002420754,0.0004889682,0.0005522449,0.0007998378,0.001175955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000439928,"about_ca_system_score_gemma":0.0005320074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002570797,"about_ca_topic_score_gemma":0.0004157769,"domain_scores_codex":[0.999757,0.00002132388,0.00002097838,0.00006579427,0.0000949441,0.00003996985],"domain_scores_gemma":[0.9998833,0.00001456014,0.00002946485,0.00001447345,0.00003106463,0.0000271372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002410893,0.00005081837,0.00138632,0.0001722598,0.00002095458,0.00004637579,0.00001365595,0.0003566371,0.9821072,0.0002347047,0.001010914,0.01435907],"study_design_scores_gemma":[0.00007890503,0.001018703,0.01536543,0.00004883259,0.0002234697,0.0007082018,0.00008413827,0.01028282,0.9401337,0.0006469968,0.03137697,0.00003181063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8964517,0.01537521,0.06009996,0.001145643,0.0003886895,0.0005294479,0.01528548,0.001736559,0.008987362],"genre_scores_gemma":[0.8367159,0.009883233,0.09423207,0.0009349344,0.0001703498,0.0005246202,0.04357495,0.0002853152,0.01367853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002092942,"threshold_uncertainty_score":0.007001519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3662698473752391,"score_gpt":0.5264424264069669,"score_spread":0.1601725790317278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}