{"id":"W4296130424","doi":"10.1158/1557-3265.sarcomas22-pr003","title":"Abstract PR003: YAP1 is a key regulator of EWS-FLI1-dependent malignant transformation upon IGF1 mediated reprogramming of bone mesenchymal stem cell-like cells","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Mesenchymal stem cell; Biology; Reprogramming; Cancer research; Cre recombinase; Cell biology; Embryonic stem cell; Conditional gene knockout; Carcinogenesis; Progenitor cell; Stem cell; YAP1; Phenotype; Transcription factor; Transgene; Genetically modified mouse; Genetics; Cell; Cancer; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160993,0.0003785888,0.0001705812,0.000185565,0.0001451514,0.0002133708,0.0001782861,0.0002450709,0.002526206],"category_scores_gemma":[0.00007622464,0.0001165607,0.0002035923,0.0001040543,0.000225532,0.0001311553,0.0002308668,0.0004951393,0.0006767284],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002415797,"about_ca_system_score_gemma":0.0001420328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003986797,"about_ca_topic_score_gemma":0.0004805784,"domain_scores_codex":[0.9998835,0.00001263066,0.00001009433,0.00003198008,0.00003473438,0.00002696619],"domain_scores_gemma":[0.9999136,0.00001344009,0.00003246312,0.000007792633,0.00000715125,0.00002559765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004268305,0.000005817605,0.00009295074,0.00001516404,0.000001095751,0.00004069727,0.000004178149,0.00001746496,0.9994192,0.00003299175,0.0000216536,0.0003062054],"study_design_scores_gemma":[0.000009693503,0.0001074734,0.004971939,0.000004304498,0.000008487453,0.0003125038,0.00002385489,0.0005894885,0.9920716,0.0000264033,0.001871757,0.000002494281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924987,0.001235502,0.003551912,0.0001086489,0.00002968949,0.00002831754,0.001128395,0.0001500526,0.001268833],"genre_scores_gemma":[0.9935706,0.0003574836,0.0009983514,0.00004171723,0.000007089356,0.00003803211,0.001435073,0.00004254543,0.003509126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002526206,"threshold_uncertainty_score":0.008450985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0930435449656888,"score_gpt":0.401289517161363,"score_spread":0.3082459721956742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}