{"id":"W4296130436","doi":"10.1158/1557-3265.sarcomas22-pr006","title":"Abstract PR006: Multi-modal single-cell profiling of sarcomas from archival tissue reveals mechanisms of resistance to immune checkpoint inhibitors","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Cancer research; Sarcoma; Melanoma; Immune checkpoint; Gene expression profiling; Immune system; Genetics; Immunotherapy; Pathology; Medicine; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001950377,0.0001475263,0.0001642295,0.0004356254,0.0001523325,0.000364661,0.0001640001,0.0002347275,0.001385246],"category_scores_gemma":[0.0002207168,0.0001136556,0.0001522196,0.0002454256,0.0001602859,0.0001391355,0.0002503447,0.0003078449,0.0005284126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001253356,"about_ca_system_score_gemma":0.0001067213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004467894,"about_ca_topic_score_gemma":0.0009188263,"domain_scores_codex":[0.9998727,0.00001018975,0.00000882692,0.00004598639,0.000041837,0.00002042096],"domain_scores_gemma":[0.9998944,0.00002088577,0.00002149689,0.00002300202,0.0000223923,0.00001783078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001052837,0.000009840387,0.007186423,0.00002522589,0.000008991737,0.00008744216,0.00004330559,0.0001285118,0.986441,0.00005024303,0.0001806442,0.005733246],"study_design_scores_gemma":[0.00001770721,0.000348163,0.2304539,0.00001363784,0.00005890825,0.003124832,0.0002615647,0.007681011,0.7497224,0.0003455191,0.007957546,0.00001490755],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9842993,0.0004531002,0.0109853,0.00009208398,0.00001334166,0.00004246178,0.0027059,0.0002408385,0.001167662],"genre_scores_gemma":[0.9870139,0.0001991314,0.008400789,0.00006721772,0.00001060722,0.00003539369,0.002831986,0.00006409013,0.001377002],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001385246,"threshold_uncertainty_score":0.004634082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09436888889503806,"score_gpt":0.4111122386363418,"score_spread":0.3167433497413037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}