{"id":"W4296130471","doi":"10.1158/1557-3265.sarcomas22-ia022","title":"Abstract IA022: Arginine, serine, xCT and ME, the therapeutic metabolism of different sarcomas","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Arginine; Downregulation and upregulation; Cancer research; Biology; Argininosuccinate synthase; Arginine deiminase; Osteosarcoma; Metabolic pathway; Cell biology; Metabolism; Biochemistry; Arginase; Amino acid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002934887,0.0004876442,0.000311608,0.000443768,0.0002077674,0.0006808586,0.0002704952,0.0004213859,0.005303877],"category_scores_gemma":[0.0001775829,0.0001428263,0.0003036773,0.0005101247,0.0001850323,0.0003539371,0.0003995521,0.001011874,0.001823313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006281727,"about_ca_system_score_gemma":0.0004516153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006127111,"about_ca_topic_score_gemma":0.0006616823,"domain_scores_codex":[0.9998491,0.00002399555,0.00001225306,0.00003011232,0.00005859155,0.00002588072],"domain_scores_gemma":[0.9999123,0.000008588029,0.00002017873,0.000008142009,0.00001814734,0.00003271612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001646192,0.0001724289,0.000933533,0.0005361115,0.00004972291,0.0003034828,0.00004583831,0.0003967776,0.934443,0.001594471,0.007092313,0.05278617],"study_design_scores_gemma":[0.0002238668,0.002661629,0.009979175,0.0000973355,0.0001478623,0.003903888,0.00008041847,0.001278566,0.7877585,0.000992803,0.1928366,0.00003937415],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.7520359,0.159559,0.0120761,0.006950738,0.003065183,0.0003610122,0.006876983,0.001262884,0.05781223],"genre_scores_gemma":[0.8933474,0.03595173,0.006454043,0.001302644,0.0005852284,0.0002062938,0.008830059,0.0002564706,0.05306619],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.005303877,"threshold_uncertainty_score":0.01774329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1244177356557479,"score_gpt":0.4802922963051505,"score_spread":0.3558745606494026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}