{"id":"W4296130477","doi":"10.1158/1557-3265.sarcomas22-a038","title":"Abstract A038: Enrollment of pediatric and adolescent patients with MAGE-A4+ advanced synovial sarcoma into cohort 2 of SPEARHEAD-1: a phase 2 trial of afamitresgene autoleucel (“afami-cel” [formerly ADP-A2M4])","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Synovial sarcoma; Sarcoma; Cohort; Internal medicine; Soft tissue sarcoma; Oncology; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001196083,0.0005470949,0.0007255424,0.0002300553,0.0005301383,0.0006993558,0.0005553497,0.0007606536,0.01373992],"category_scores_gemma":[0.001282996,0.0003457554,0.001026129,0.0003339263,0.0003342894,0.0005674131,0.0004481964,0.001634839,0.001965365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009419319,"about_ca_system_score_gemma":0.002688161,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0016937,"about_ca_topic_score_gemma":0.004363028,"domain_scores_codex":[0.9994575,0.0002292695,0.00003986737,0.0001410987,0.00005008291,0.00008208699],"domain_scores_gemma":[0.9992218,0.00008011013,0.0001393359,0.00004711561,0.00005077842,0.0004608463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5751719,0.03422591,0.1936099,0.0009904589,0.001917723,0.001373429,0.000946463,0.001132384,0.02192541,0.0009767682,0.03829085,0.1294388],"study_design_scores_gemma":[0.4183897,0.2702828,0.2540416,0.0003571137,0.001731812,0.00221496,0.0007344357,0.002303047,0.006550513,0.001261851,0.04205131,0.00008079367],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746706,0.001156322,0.0007517579,0.0009999995,0.0001871834,0.008946642,0.009346068,0.00008801719,0.003853393],"genre_scores_gemma":[0.9701791,0.0009072522,0.002482584,0.001957416,0.0002574787,0.01070762,0.00991598,0.0000405526,0.003552016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01373992,"threshold_uncertainty_score":0.0459646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0989514237550265,"score_gpt":0.4819774249748727,"score_spread":0.3830260012198462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}