{"id":"W4296131130","doi":"10.1158/1557-3265.sarcomas22-pr010","title":"Abstract PR010: Development of a pre-clinical metastatic model of human sarcoma to identify therapeutic targets","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Sarcoma; Medicine; Metastasis; Disease; Mesenchymal stem cell; Cancer research; In vivo; Radiation therapy; Cancer; Oncology; Pathology; Bioinformatics; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000714143,0.0005366927,0.0003765995,0.0006663501,0.000421063,0.0005402245,0.0007967736,0.0008216446,0.004488297],"category_scores_gemma":[0.0002718647,0.0003310112,0.0005552152,0.000282547,0.0005167089,0.0004767556,0.0004898478,0.002148624,0.001933862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006535486,"about_ca_system_score_gemma":0.001066461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003377126,"about_ca_topic_score_gemma":0.003232219,"domain_scores_codex":[0.9994548,0.00006845053,0.00005568174,0.0001206954,0.0002204809,0.00007992914],"domain_scores_gemma":[0.999624,0.00006564627,0.000073651,0.00005839936,0.00006006927,0.000118265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001816143,0.0003172707,0.0002378032,0.00009482451,0.00000937866,0.0001782396,0.000048671,0.0004930654,0.9926633,0.001146754,0.0008359185,0.003793254],"study_design_scores_gemma":[0.0001039277,0.001858548,0.001581243,0.00003712378,0.00003354276,0.001028514,0.0000679599,0.004922212,0.9725027,0.0003133426,0.0175324,0.00001849191],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.840219,0.003370468,0.1127859,0.001651784,0.0009122477,0.001937369,0.00951143,0.001867329,0.02774432],"genre_scores_gemma":[0.9015051,0.002008675,0.05369327,0.0004112362,0.00004612963,0.001107859,0.006336822,0.0003137671,0.03457708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004488297,"threshold_uncertainty_score":0.01501483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3225598937781,"score_gpt":0.5619909653106611,"score_spread":0.2394310715325611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}