{"id":"W4296131254","doi":"10.1158/1557-3265.sarcomas22-a005","title":"Abstract A005: STING activation overcomes immune escape in osteosarcoma metastasis","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Sting; Stimulator of interferon genes; Cancer research; Metastasis; Immune system; Cancer; Tumor microenvironment; Cancer cell; Downregulation and upregulation; Medicine; Immunotherapy; Innate immune system; Immunology; Biology; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131733,0.0002768826,0.0002907629,0.0002529344,0.0001231279,0.0003502193,0.0001882761,0.0002906587,0.005720409],"category_scores_gemma":[0.0001098572,0.00008671082,0.0003058967,0.0001334563,0.0001747352,0.0002140765,0.0001697322,0.0008963323,0.0006963256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002373717,"about_ca_system_score_gemma":0.0003174897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004880837,"about_ca_topic_score_gemma":0.0007914157,"domain_scores_codex":[0.999912,0.00001229307,0.00000866299,0.00001330019,0.00002057057,0.00003306977],"domain_scores_gemma":[0.9999328,0.000007659196,0.00001415139,0.000006100012,0.000008716515,0.00003063637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001230341,0.0003703598,0.00056132,0.0002253732,0.00002501295,0.0001073384,0.00002647634,0.0002592244,0.978144,0.0006655125,0.0009401466,0.01744489],"study_design_scores_gemma":[0.0003851329,0.008614569,0.009812902,0.00005270177,0.0001185984,0.0005299409,0.0001028674,0.003324313,0.9541004,0.0004284937,0.02251594,0.000014117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848226,0.004707773,0.002280813,0.0005560616,0.0003041192,0.00009952517,0.0006984852,0.0003647819,0.006165824],"genre_scores_gemma":[0.992176,0.001277278,0.0007411495,0.0001239853,0.00003775415,0.00004072464,0.000556647,0.00001795504,0.005028555],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005720409,"threshold_uncertainty_score":0.01913667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2258479391527367,"score_gpt":0.49713505180734,"score_spread":0.2712871126546033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}