{"id":"W4296131396","doi":"10.1158/1557-3265.sarcomas22-a019","title":"Abstract A019: Phase 1, first-in-human, dose-expansion study of oral TP-1287, a cyclin dependent kinase 9 (CDK9) inhibitor, in patients with sarcoma","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Sarcoma; Internal medicine; Cancer; Oncology; Synovial sarcoma; Neutropenia; Chemotherapy; Gastroenterology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003285767,0.0002702635,0.0009052093,0.0005965735,0.0002390314,0.00001814294,0.0004460236,0.0001172332,0.001079956],"category_scores_gemma":[0.0003487401,0.0002297883,0.0001136744,0.001214216,0.0003806801,0.0001633992,0.0005151868,0.002470928,0.000008471774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001121917,"about_ca_system_score_gemma":0.0007185579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005763538,"about_ca_topic_score_gemma":0.0103744,"domain_scores_codex":[0.9937534,0.0007310915,0.001387761,0.0009382754,0.002394598,0.0007948526],"domain_scores_gemma":[0.9974793,0.0006621245,0.0002647516,0.0008508223,0.0004216213,0.0003213802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03218053,0.02851172,0.8893899,0.000149342,0.000093655,0.0004903864,0.001141209,0.0009126308,0.0004194341,0.000005958276,0.0001463219,0.0465589],"study_design_scores_gemma":[0.0674361,0.01598914,0.9120143,0.0003374488,0.00002926395,0.000002377375,0.002259578,0.00005387802,0.000273679,0.00009707997,0.001269236,0.0002378853],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957153,0.0004687101,0.000002808293,0.0005525306,0.0002268221,0.002842667,0.00007103219,0.00003076118,0.00008934266],"genre_scores_gemma":[0.9984697,0.00005285888,0.00007389503,0.0001252588,0.000148787,0.0008847288,0.00004114401,0.00007339937,0.0001302575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04632102,"threshold_uncertainty_score":0.9998332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1326258791109277,"score_gpt":0.5003120973935415,"score_spread":0.3676862182826138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}