{"id":"W4296131396","doi":"10.1158/1557-3265.sarcomas22-a019","title":"Abstract A019: Phase 1, first-in-human, dose-expansion study of oral TP-1287, a cyclin dependent kinase 9 (CDK9) inhibitor, in patients with sarcoma","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Sarcoma; Internal medicine; Cancer; Oncology; Synovial sarcoma; Neutropenia; Chemotherapy; Gastroenterology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009808639,0.001333873,0.001248731,0.0003309522,0.0004687973,0.0007650065,0.0006815477,0.0008882098,0.006673819],"category_scores_gemma":[0.0006878813,0.0005719257,0.0007506848,0.000313005,0.0006872421,0.0008227881,0.0004027602,0.003276041,0.001941559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007520699,"about_ca_system_score_gemma":0.001841305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006925503,"about_ca_topic_score_gemma":0.001746074,"domain_scores_codex":[0.9997637,0.00009696529,0.0000158775,0.00004387281,0.00003183358,0.00004780814],"domain_scores_gemma":[0.9995259,0.00008727568,0.0000825462,0.00003235887,0.00003503072,0.0002369012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4496842,0.2284405,0.01948435,0.00158145,0.0008293166,0.001205575,0.000745134,0.004979037,0.1400502,0.0006447798,0.01175701,0.1405986],"study_design_scores_gemma":[0.3591735,0.6143159,0.01355024,0.00004918676,0.0002047104,0.0007383417,0.0001066571,0.001268087,0.006041717,0.0002529407,0.004271301,0.00002737332],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907188,0.0007101669,0.0007537877,0.0003303942,0.00006217652,0.003548409,0.001579427,0.0001034768,0.002193466],"genre_scores_gemma":[0.9847612,0.001026431,0.002187817,0.0008897249,0.0001056942,0.003444199,0.003214162,0.0000387175,0.004332009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006673819,"threshold_uncertainty_score":0.02232611,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1326258791109277,"score_gpt":0.5003120973935415,"score_spread":0.3676862182826138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}