{"id":"W4296131781","doi":"10.1158/1557-3265.sarcomas22-ia019","title":"Abstract IA019: How to target lung metastasis: dynamic changes in chromatin accessibility during osteosarcoma lung metastasis expose vulnerabilities","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Metastasis; Reprogramming; Osteosarcoma; Chromatin; Cancer research; Biology; Transcription factor; Lung cancer; Epigenomics; Context (archaeology); Cancer; Medicine; Pathology; Cell; DNA methylation; Genetics; Gene expression","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587803,0.0003099189,0.0003168931,0.0002515731,0.000254346,0.0005024881,0.0002333729,0.0004154964,0.005850504],"category_scores_gemma":[0.0001810157,0.0002198133,0.000232118,0.0002036073,0.0002669829,0.0002696131,0.0003274728,0.0009047104,0.001451264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004371254,"about_ca_system_score_gemma":0.0003735986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001374859,"about_ca_topic_score_gemma":0.003086096,"domain_scores_codex":[0.9998668,0.000008450334,0.000008796615,0.00002616449,0.00006419102,0.00002540399],"domain_scores_gemma":[0.9998894,0.00001976237,0.00002671012,0.00001570721,0.0000188298,0.00002964582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000489701,0.000012291,0.0003574871,0.00005007979,0.000003686549,0.00007341684,0.00001618444,0.0001167357,0.9920245,0.0002768314,0.000697994,0.006321804],"study_design_scores_gemma":[0.00002513839,0.0003140171,0.008539244,0.00002244574,0.00003120618,0.0005972208,0.0000598763,0.0009686803,0.9566348,0.0003236244,0.03246778,0.00001608963],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8725878,0.01519394,0.04854055,0.004206283,0.0007176475,0.000445875,0.0053007,0.003614963,0.04939233],"genre_scores_gemma":[0.9377618,0.004931234,0.01187882,0.0006728031,0.00006585204,0.0001277931,0.002453426,0.0003468096,0.04176135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005850504,"threshold_uncertainty_score":0.01957184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07549966012525675,"score_gpt":0.4429263766585873,"score_spread":0.3674267165333306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}