{"id":"W4296131819","doi":"10.1158/1557-3265.sarcomas22-ia010","title":"Abstract IA010: Novel targeted therapy approaches in NF1-MPNST","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Neurofibromatosis and Schwannoma Cases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Cancer research; CDKN2A; Medicine; Targeted therapy; MAPK/ERK pathway; MEK inhibitor; Kinase; Cancer; Small molecule; Trametinib; Receptor tyrosine kinase; Internal medicine; Biology; Receptor; Cell biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001851516,0.0003492764,0.0002529527,0.0005937045,0.0002471643,0.0004748441,0.000460688,0.0003465227,0.006363682],"category_scores_gemma":[0.00006483794,0.0001096158,0.0003143112,0.0002905345,0.0002075907,0.0002533619,0.0002635231,0.000623334,0.001201001],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009737117,"about_ca_system_score_gemma":0.0007588262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003560861,"about_ca_topic_score_gemma":0.009096949,"domain_scores_codex":[0.9999566,0.000005159319,0.000001883195,0.000009265073,0.00001472412,0.00001224564],"domain_scores_gemma":[0.9999764,0.000002602271,0.000003714678,0.000001364852,0.000005472777,0.00001039977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001399348,0.0007917467,0.001252501,0.001058823,0.00006419769,0.0007271746,0.0001164221,0.001641552,0.394966,0.00760786,0.02720814,0.5631663],"study_design_scores_gemma":[0.001477479,0.009374569,0.02164166,0.0005375402,0.0003407634,0.00723944,0.0001579855,0.006598088,0.3389963,0.003331195,0.6102177,0.00008725504],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4392213,0.3406316,0.03870039,0.007895877,0.002964098,0.001137244,0.002796664,0.002001242,0.1646516],"genre_scores_gemma":[0.6826916,0.1609938,0.02433148,0.001644886,0.0006349542,0.0004939396,0.002587843,0.0001634697,0.1264581],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006363682,"threshold_uncertainty_score":0.02128869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5848092251588513,"score_gpt":0.5210043826787708,"score_spread":0.06380484248008045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}