{"id":"W4296148410","doi":"10.2139/ssrn.4208348","title":"Rapid, Scalable, and Combinatorial Genome Engineering by Markerless Enrichment and Recombination of Genetically Engineered Loci (MERGE) in Yeast","year":2022,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Concordia University","funders":"","keywords":"Genome engineering; Merge (version control); Genetically engineered; Genome; Recombination; Yeast; Genetics; Homologous recombination; Computational biology; Biology; Scalability; Computer science; Genome editing; DNA; Gene; Parallel computing; Database","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009125564,0.0008500654,0.001281066,0.000791177,0.0004395879,0.001509402,0.001230224,0.0004368958,0.001339755],"category_scores_gemma":[0.0005873475,0.0007457067,0.0009377125,0.0006741,0.0004886742,0.0007031501,0.002297191,0.002094881,0.00197946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004468554,"about_ca_system_score_gemma":0.0004989735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006730141,"about_ca_topic_score_gemma":0.001244569,"domain_scores_codex":[0.9988199,0.000103309,0.0001148198,0.0002737026,0.0005487633,0.000139454],"domain_scores_gemma":[0.9996423,0.00006406036,0.00008167294,0.00009906555,0.00004754632,0.00006541392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001653302,0.00006023141,0.0002947298,0.0001154298,0.00002261886,0.00004793113,0.00003701338,0.0008262714,0.9831803,0.0006021775,0.0003617523,0.01428611],"study_design_scores_gemma":[0.00003947077,0.0001413976,0.0006385191,0.000008725157,0.00002891593,0.0002392495,0.00003819521,0.003834161,0.9891857,0.000321179,0.005491096,0.00003341984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4463105,0.002868678,0.5275376,0.0006313866,0.0002389736,0.0006908511,0.004491295,0.0130839,0.004146928],"genre_scores_gemma":[0.5379822,0.002377284,0.4437106,0.0001605738,0.00004769071,0.0005043548,0.008133733,0.001546097,0.005537485],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001509402,"threshold_uncertainty_score":0.004826128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003419389412599443,"score_gpt":0.201900618954962,"score_spread":0.1984812295423626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}