{"id":"W4296157783","doi":"10.1101/2022.09.15.22280011","title":"Germ cell-specific proteins ACRV1 and AKAP4 facilitate identification of rare spermatozoa in semen of non-obstructive azoospermia patients","year":2022,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Sunnybrook Hospital; University of Toronto; CReATe Fertility Centre","funders":"Canadian Institutes of Health Research; Astellas Pharma; University of Alberta; Prostate Cancer Canada; Movember Foundation","keywords":"Semen; Andrology; Azoospermia; Flow cytometry; Biology; Germ cell; Testicular sperm extraction; Male infertility; Sperm; Microdissection; Infertility; Molecular biology; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000413003,0.0003284145,0.0002729367,0.001084012,0.0002347324,0.000591782,0.0002364787,0.000379682,0.001390041],"category_scores_gemma":[0.0007394471,0.0001080922,0.0002636502,0.0004077651,0.0002127125,0.0002035345,0.0002953322,0.0002545995,0.0002604468],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001551327,"about_ca_system_score_gemma":0.0001343994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000566092,"about_ca_topic_score_gemma":0.0005836564,"domain_scores_codex":[0.9998123,0.00003454369,0.0000276796,0.00005302351,0.0000484371,0.00002409862],"domain_scores_gemma":[0.9998285,0.00005018643,0.00004844929,0.00001046095,0.00003219948,0.00003025718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00132661,0.0001248941,0.4894606,0.0004513038,0.0002319179,0.003203608,0.0004915892,0.0005353608,0.4532516,0.0004675975,0.000959059,0.04949594],"study_design_scores_gemma":[0.00005017664,0.001250408,0.8029041,0.0001178152,0.0002603469,0.01310395,0.0006678706,0.005188741,0.1688088,0.0005490381,0.007060379,0.00003832054],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932667,0.00313004,0.00224483,0.0001363239,0.00003031254,0.0000301391,0.0005483325,0.0000749145,0.0005384352],"genre_scores_gemma":[0.9961762,0.0007046089,0.001989774,0.0000818185,0.00001986041,0.0000137481,0.0005064488,0.000007620436,0.0005000042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390041,"threshold_uncertainty_score":0.004650176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01735475360158651,"score_gpt":0.2441213198898693,"score_spread":0.2267665662882828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}