{"id":"W4296163306","doi":"10.1038/s41388-022-02426-3","title":"Forming cytoplasmic stress granules PURα suppresses mRNA translation initiation of IGFBP3 to promote esophageal squamous cell carcinoma progression","year":2022,"lang":"en","type":"article","venue":"Oncogene","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"National Natural Science Foundation of China","keywords":"Biology; Messenger RNA; RNA-binding protein; Internal ribosome entry site; Stress granule; Translation (biology); Molecular biology; RNA; Untranslated region; Cytoplasm; Eukaryotic initiation factor; Protein biosynthesis; Initiation factor; Cancer research; Cell biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219597,0.0001163504,0.0001133868,0.00006875157,0.0001811726,0.00001367198,0.0001710102,0.0000589208,0.00005412207],"category_scores_gemma":[0.00001023459,0.0001200809,0.00006898677,0.000143021,0.00002088105,0.000008671705,0.00007211006,0.0000652064,0.000001791115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003137905,"about_ca_system_score_gemma":0.00009625294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002961317,"about_ca_topic_score_gemma":0.00003138761,"domain_scores_codex":[0.9990469,0.0000597038,0.0002342212,0.0002762836,0.000212317,0.0001705335],"domain_scores_gemma":[0.9994769,0.000008017046,0.0001281151,0.0002546376,0.00007519582,0.00005718028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001382063,0.0001673235,0.002220479,0.00005685776,0.000005973895,0.000003100653,0.0003276428,0.00151065,0.9727809,0.00001431958,0.0002136079,0.02256092],"study_design_scores_gemma":[0.0005985534,0.0005696848,0.001395714,0.000006688774,0.00002417329,0.000007874598,0.0001349659,0.0002904872,0.9870107,0.00002266155,0.009802242,0.0001362239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956094,0.001631637,0.001298898,0.0001072825,0.00009934025,0.0004190189,0.0002985634,0.00001056653,0.0005253043],"genre_scores_gemma":[0.9973035,0.00003107649,0.001472154,0.00003674812,0.0001067693,0.0002110267,0.0006228365,0.00002268221,0.0001931682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02242469,"threshold_uncertainty_score":0.4896758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01461392908492576,"score_gpt":0.2655919609537091,"score_spread":0.2509780318687833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}