{"id":"W4296164016","doi":"10.1016/j.jaad.2022.09.010","title":"Itch-free state in patients with atopic dermatitis treated with ruxolitinib cream: A pooled analysis from two randomized phase 3 studies","year":2022,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Cilag; Bausch Health; Galderma; Astellas Pharma; Sanofi; Kyowa Hakko Kirin; Glenmark Pharmaceuticals; InflaRx; Pfizer; Incyte; Sun Pharma; Dermira; Les Laboratories Pierre Fabre; Celldex Therapeutics; Coherus Biosciences; UCB Pharma; Valeant Pharmaceuticals International; Sanofi Genzyme; Daewoong Pharmaceutical Company; Regeneron Pharmaceuticals; Meiji Seika Pharma; Kiniksa Pharmaceuticals; Baxalta; LEO Pharma; Ortho Dermatologics; Gilead Sciences; GlaxoSmithKline; Amgen; Celgene; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Ruxolitinib; Atopic dermatitis; Dermatology; Randomized controlled trial; Dupilumab; Internal medicine; Myelofibrosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02150144,0.001630278,0.00861144,0.001245271,0.0003261605,0.002463655,0.0009182027,0.001769906,0.00294886],"category_scores_gemma":[0.03209642,0.0007139784,0.01785809,0.00175858,0.0005700029,0.001325907,0.0007096558,0.001965026,0.0002338931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006211575,"about_ca_system_score_gemma":0.0008147346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004457896,"about_ca_topic_score_gemma":0.001134099,"domain_scores_codex":[0.9880551,0.007417953,0.002478703,0.0009533251,0.0008060497,0.0002890527],"domain_scores_gemma":[0.9654225,0.02330317,0.007701063,0.001470201,0.001515102,0.0005880093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.2851693,0.0003040581,0.02019119,0.04109199,0.6140525,0.0002865632,0.00008951296,0.0009245544,0.001370505,0.0002069622,0.002898772,0.0334142],"study_design_scores_gemma":[0.1013132,0.008634775,0.03857618,0.002793692,0.8417567,0.0003232482,0.00008309634,0.001254059,0.0007121016,0.0006259435,0.003808533,0.000118476],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3161882,0.6628324,0.004200641,0.003328033,0.003165678,0.001973073,0.006086661,0.0001958521,0.002029445],"genre_scores_gemma":[0.9414471,0.04513286,0.002767366,0.003447335,0.002660017,0.001297674,0.0026147,0.000057522,0.0005753448],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02150144,"threshold_uncertainty_score":0.1137118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01098293709725651,"score_gpt":0.3066543099311879,"score_spread":0.2956713728339314,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}