{"id":"W4296167821","doi":"10.1016/j.cbpa.2022.102211","title":"Insights into SACS pathological attributes in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS)☆","year":2022,"lang":"en","type":"review","venue":"Current Opinion in Chemical Biology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"Canadian Institutes of Health Research","keywords":"Biology; Phenotype; Gene; Ataxia; Genetics; Computational biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001557592,0.000677213,0.002056137,0.0005044566,0.000061944,0.00001648299,0.001215184,0.0004686583,0.000209608],"category_scores_gemma":[0.004345892,0.0005485222,0.0003925178,0.001154759,0.0006841928,0.0000576089,0.001118905,0.001351939,0.00004484273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002487931,"about_ca_system_score_gemma":0.0003364332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005466289,"about_ca_topic_score_gemma":0.000001405062,"domain_scores_codex":[0.9939694,0.001908716,0.001513214,0.001695231,0.0003136219,0.0005998593],"domain_scores_gemma":[0.9962584,0.002232058,0.0007275159,0.0005661672,0.00004136153,0.0001744472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001122317,0.002446583,0.001580483,0.01811408,0.00002497209,0.00005288758,0.0002679092,0.00001684294,0.0925834,0.002702692,0.0009472479,0.8811507],"study_design_scores_gemma":[0.0007679791,0.0003060846,0.0001196848,0.004021224,0.00005934899,0.00003035319,0.00001141699,0.00003868256,0.02705347,0.001853261,0.9648275,0.000911042],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02929587,0.9656616,0.00001917207,0.00004319396,0.00347226,0.0009617345,0.000475024,0.00004426247,0.00002691587],"genre_scores_gemma":[0.01307883,0.9849104,0.00003113232,0.00003064391,0.0002760364,0.0007193162,0.0009062185,0.00004205774,0.000005357243],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9638802,"threshold_uncertainty_score":0.9996966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1648597479131494,"score_gpt":0.3919233993610001,"score_spread":0.2270636514478507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}