{"id":"W4296171824","doi":"10.3389/fnagi.2022.958050","title":"Osteoporosis is associated with elevated baseline cerebrospinal fluid biomarkers and accelerated brain structural atrophy among older people","year":2022,"lang":"en","type":"article","venue":"Frontiers in Aging Neuroscience","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Science Foundation of Zhejiang Province; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Eli Lilly and Company; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Wenzhou Municipal Science and Technology Bureau; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cerebrospinal fluid; Atrophy; Medicine; Osteoporosis; Brain aging; Pathology; Internal medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003924002,0.000221724,0.0003724381,0.0005902399,0.0003207955,0.0004529897,0.0001867786,0.0004837536,0.001150902],"category_scores_gemma":[0.001725419,0.0001652762,0.0003385302,0.0007863917,0.0002049967,0.0002756726,0.0003109044,0.0003816407,0.0001202316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001711146,"about_ca_system_score_gemma":0.0002987461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005113123,"about_ca_topic_score_gemma":0.006780906,"domain_scores_codex":[0.9997554,0.00004723252,0.00003213881,0.00005527179,0.00006395236,0.00004592674],"domain_scores_gemma":[0.999249,0.00006844062,0.0004835096,0.00003095788,0.00008953997,0.00007843344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001870778,0.00002875829,0.9969915,0.00001958338,0.00007525398,0.00007793894,0.00004528337,0.00001692645,0.0002824961,0.00001324441,0.00005987607,0.002202029],"study_design_scores_gemma":[0.000004764604,0.00006871969,0.99941,0.000007872168,0.000036509,0.0001995704,0.00005471161,0.00005163065,0.00004898176,0.0000329888,0.00008259096,0.000001630338],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998268,0.001113168,0.00005751528,0.00007288565,0.000007770628,0.000003932867,0.0001815642,0.000004043058,0.000291034],"genre_scores_gemma":[0.999441,0.0002341314,0.00006125526,0.00002181226,0.00001408129,0.00000262699,0.00009582716,5.760994e-7,0.0001287564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005113123,"threshold_uncertainty_score":0.0101667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121499067240236,"score_gpt":0.2659145744602022,"score_spread":0.2537646677361786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}